Hypothyroidism is a common endocrine disorder where in the thyroid does not make enough thyroid hormone.
Subclinical/mild hypothyroidism refers to the state of slightly increased serum TSH with normal serum FT4 in patients who are usually asymptomatic.
Most common cause of primary hypothyroidism is autoimmune thyroiditis or Hashimoto's disease.
Levothyroxine is the first-line agent for treatment of hypothyroidism.
Roshini Claire Anthony speaks to Dr Adoree Lim, a consultant at the Department of Endocrinology, Singapore General Hospital, on how GPs can help tackle hyper- and hypothyroidism in the primary care setting.
Levothyroxine demonstrates a lowering effect on total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol in patients with subclinical hypothyroidism (SCH), including those with mild SCH, according to a systematic review and meta-analysis.
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Progressive lipolysis may be reduced via the improved antilipolytic effect in adipose tissue, which leads to a reduction in future weight loss caused by sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes (T2D), suggests a recent study.
Maternal prepregnancy obesity is associated with earlier age at voice break, pubic hair development, axillary hair and acne in sons, as well as with earlier age at menarche, breast development, pubic hair development, axillary hair and acne in daughters, a study has found. These associations appear to be mediated by higher childhood body mass index in sons and partly so in daughters.