hypogonadism%20in%20males%20-%20late-onset
HYPOGONADISM IN MALES - LATE-ONSET
Late onset hypogonadism is defined as clinical and biochemical syndrome characterized by older age, set of typical symptoms, and deficiency in serum testosterone levels.
The quality of life may be decreased and multiple organ systems may be adversely affected.
Prior to the start of testosterone substitution, there should be confirmation of low serum testosterone and a confirmation of need based on clinical findings.
Only if the potential benefit exceeds the risk, then replacement testosterone should be started.

Hypogonadism%20in%20males%20-%20late-onset Signs and Symptoms

Introduction

  • A type of hypogonadism that has normal pubertal development thus w/ developed normal male secondary sex characteristics
  • Prevalence of hypogonadism increases w/ age
  • Quality of life may be decreased
  • Multiple organ systems may be adversely affected

Definition

  • Late-onset hypogonadism (LOH) is defined as a clinical & biochemical syndrome caused by androgen deficiency characterized by:
    • Older age
    • Set of typical symptoms
    • Deficiency in serum testosterone levels

Signs and Symptoms

  • Decreased sexual desire & erectile quality & frequency; especially nocturnal erections
  • Mood changes, including:
    • Decreases in intellectual activity, cognitive function, spatial orientation ability
    • Fatigue
    • Depression
    • Irritability 
  • Sleep disturbances
  • Decrease in lean body mass w/ decrease in muscle volume & strength
  • Increase in visceral fat
  • Decrease in body hair & skin alterations
  • Osteopenia, osteoporosis & increased risk of bone fractures may develop from a decrease in bone mineral density
  • Hot flushes
Editor's Recommendations
Most Read Articles
6 days ago
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
09 Jan 2021
Women with central adiposity, regardless of menopausal status, are at risk of developing breast cancer, according to a study.