hypogonadism%20in%20males%20-%20late-onset
HYPOGONADISM IN MALES - LATE-ONSET
Late onset hypogonadism is defined as clinical and biochemical syndrome characterized by older age, set of typical symptoms, and deficiency in serum testosterone levels.
The quality of life may be decreased and multiple organ systems may be adversely affected.
Prior to the start of testosterone substitution, there should be confirmation of low serum testosterone and a confirmation of need based on clinical findings.
Only if the potential benefit exceeds the risk, then replacement testosterone should be started.

Hypogonadism in Males - Late-Onset References

  1. Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2006 Jun;91(6):1995-2010. PMID: 16720669
  2. Haren MT, Monn JK, Tariq SH, et al. Andropause: a quality-of-life issue in older males. Med Clin North Am. 2006 Sep;90(5):1005-1023. PMID: 16962854
  3. Handelsman DJ, Zajac JD. Androgen deficiency and replacement in men. Med J Aust. 2004 May;180(10):529-535. PMID: 15139833
  4. Advisory Panel of Testosterone Replacement in Men. Report of the National Institute on Aging Advisory Panel on testosterone replacement in men. J Clin Endocrinol Metab. 2001 Oct;86(10):4611-4614. PMID: 11600511
  5. Haddad RM, Kennedy CC, Caples SM, et al. Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc. 2007 Jan;82(1):29-39. PMID: 17285783
  6. Bolona ER, Uraga MV, Haddad RM, et al. Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc. 2007 Jan;82(1):20-28. PMID: 17285782
  7. Kaufman JM, Vermuelen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev. 2005 Oct;26(6):833-876. PMID: 15901667
  8. Kim YC. Hormonal replacement therapy and aging: Asian practical recommendations on testosterone supplementation. Asian J Androl. 2003 Dec;5(4):339-344. PMID: 14695985
  9. Margo K, Winn R. Testosterone treatments: why, when, and how?. Am Fam Physician. 2006 May;73(9):1591-1598. PMID: 16719252
  10. Morales A, Lunenfeld B; International Society for the Study of the Aging Male. Investigation, treatment and monitoring of late-onset hypogonadism in males. Official recommendations of ISSAM. International Society for the Study of the Aging Male. Aging Male. 2002 Jun;5(2):74-86. PMID: 12198738
  11. Vermeulen A. Androgen replacement therapy in the aging male - a critical evaluation. J Clin Endocrinol Metab. 2001 Jun;86(6):2380-2390. PMID: 11397827
  12. Snyder PJ. Effects of age on testicular function and consequences of testosterone treatment. J Clin Endocrinol Metab. 2001 Jun;86(6):2369-2372. PMID: 11397825
  13. Petak SM, Nankin HR, Spark RF, et al. American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients - 2002 update. Endocr Pract. 2002 Nov;8(6):439-456. PMID: 15260010
  14. MedWormhttp://www.medworm.com/rss/index.php/Endocrinology/15/http://www.medworm.com/rss/medicalfeeds/specialities/Endocrinology.xml
  15. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  16. Singapore Urological Association. Andropause guidelines. http://www.sua.org.sg/. Oct 2006
  17. International Society of Andrology, International Society for the Study of the Aging Male, European Association of Urology. Investigation, treatment and monitoring of late-onset hypogonadism in males. http://www.uroweb.org/fileadmin/user_upload/Guidelines/14%20Hypogonadism.pdf. Jun 2006
  18. Bhasin S, Cunningham GR, Hayes FJ, et al. Clinical guidelines. Testosterone therapy in adult men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010 Jun;95(6):2536-2559. doi: 10.1210/jc.2009-2354. Accessed 9 Oct 2014. PMID: 20525905
  19. Dandona P, Rosenberg MT. A practical guide to male hypogonadism in the primary care setting. Int J Clin Pract. 2010 May;64(6):682-696. doi: 10.1111/j.1742-1241.2010.02355.x. PMID: 20518947
  20. Dohle GR, Arver S, Bettocchi C, et al. Guidelines on male hypogonadism. European Association of Urology . www.uroweb.org/gls/pdf/16_Male_Hypogonadism_LR%20II.pdf. 2012.
  21. Thorner M, Buchner D, Clemmons D, et al. Report of the National Institute on Aging Advisory Panel on testosterone replacement in men. J Clin Endocrinol Metab. 2001;86(10):4611-4614.
  22. Young CK. Hormonal replacement therapy and aging: Asian practical recommendations on testosterone supplementation. Asian J Androl. 2003 Dec;5:339-344.
  23. Dohle GR, Arver S, Bettochi C, et al. Guidelines on male hypogonadism. European Association of Urology. http://uroweb.org/wp-content/uploads/18-Male-Hypogonadism_LR.pdf. 2014.
  24. Surampudi P, Swerdloff RS, Wang C. An update on male hypogonadism therapy. Expert Opin Pharmacother. 2014 Jun;15(9):1247-1264. doi: 10.1517/14656566.2014.913022. PMID: 24758365
  25. Dohle GR, Arver S, Bettochi C, et al. Guidelines on male hypogonadism. European Association of Urology. http://uroweb.org/guideline/male-hypogonadism/. 2015.
  26. Morales A, Bebb RA, Manjoo P, et al. Diagnosis and management of testosterone deficiency syndrome in men: clinical practice guideline. CMAJ. 2015 Dec;187(18):1369-1377. doi: 10.1503/cmaj.150033. PMID: 26504097
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