hyperthyroidism
HYPERTHYROIDISM
Hyperthyroidism is the overactivity of the thyroid gland resulting in excessive production of thyroid hormones.
Symptoms are of gradual onset.
Earliest signs may be emotional lability and motor hyperactivity; decline in school performance may also be noted.
Causes are autoimmune (Grave's disease), inappropriate stimulation by trophic factors, passive release of preformed thyroid hormone stores in response to infections, trauma, or other offensive factors inside the body, and extra-thyroidal sources.

Follow Up

  • Patients on antithyroid drug therapy w/ Methimazole should be monitored after initiation of therapy
    • Monitoring of thyroid function tests should be done at 1 month after initiation, then every 2-4 months thereafter
  • Doses of antithyroid medications should be discontinued or titrated after 1-2 years of continuous treatment, to assess for disease remission
  • Lifelong monitoring of thyroid function is advised for all patients previously prescribed w/ antithyroid drug therapy
  • Instruct the parents/guardians of patients to immediately report signs of liver dysfunction (jaundice, pruritus, rash, anorexia, right upper quadrant pain, light-colored stool, dark urine)
  • Consider radioactive iodine therapy or surgery in patients on antithyroid therapy (Methimazole) for >1-2 years
  • Relapse after discontinuation of therapy occurs in 3-47% of pediatric population
    • Studies show that relapse usually occurs w/in 1 year after treatment discontinuation
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS JPOG - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elaine Soliven, 17 Aug 2017
Probiotic supplementation during the first 6 months of life does not reduce the incidence of eczema or asthma later in childhood, according to the randomized controlled TIPS* study.