hyperparathyroidism
HYPERPARATHYROIDISM

Hyperparathyroidism is a condition wherein there is an excessive production of parathyroid hormone (PTH).

Primary hyperparathyroidism is the most common endocrine disorder and an important cause of hypercalcemia in ambulatory patients.

Classic signs and symptoms include bone disease, kidney stones and hypercalcinosis.

Primary goal of pharmacological therapy is to normalize calcium levels.

 

Definition

  • Caused by excessive parathyroid hormone (PTH) production

Signs and Symptoms

  • Usually related to elevated levels of PTH & serum calcium
  • Classic signs & symptoms include bone disease, kidney stones & hypercalcinosis
  • Constipation
  • Hypertension
  • Muscle weakness
  • Nausea
  • Polydipsia
  • Polyuria
  • Psychiatric symptoms (depression, anxiety, etc)
  • Significant loss of appetite

Epdemiology

  • Primary hyperparathyroidism is the most common endocrine cause of hypercalcemia in ambulatory patients
  • Occurs more in women than in men aged >50 years old
  • 85-95% of primary hyperparathyroidism is due to adenoma
  • Sporadically arising solitary parathyroid adenoma is the most common primary hyperparathyroidism (PHPT)
  • Familial syndromes - 2nd most common cause of PHPT
  • Renal failure - most common cause of secondary hyperparathyroidism
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