The antiresorptive agent denosumab, used alone or in combination with the calcimimetic agent cinacalcet, improves BMD and reduces bone turnover in patients with primary hyperparathyroidism (PHPT) — providing a potential treatment option for patients in whom surgery is undesirable, the DENOCINA* trials has shown.
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A low-carbohydrate diet increases energy expenditure during weight loss maintenance, consistent with the carbohydrate-insulin model, a study has shown. This metabolic effect may contribute to the success of obesity treatment, particularly among those with high insulin secretion.
A hospital-based observational cohort study finds an association between higher fasting blood glucose (FBG) levels and unfavourable outcomes, including death, among Chinese patients with diabetes mellitus (DM) following acute ischaemic stroke (AIS).