hodgkin's%20lymphoma
HODGKIN'S LYMPHOMA

Hodgkin's lymphoma is a malignancy that arises from germinal center B cell.

Histologically, there is a presence of multinucleated giant cells in a mixed inflammatory background.

It is also known as Hodgkin's disease, Hodgkin lymphoma or Hodgkin disease.

It commonly affects individuals ages 15-30 years old and those 55 years old and above.

The key morphologic characteristics include presence of Reed-Sternberg cells and lymphocyte-predominant cells.

Introduction

  • Also known as Hodgkin’s disease, Hodgkin lymphoma, or Hodgkin disease
  • Commonly affects ages 15-30 years old, & individuals 55 years old & above
  • Key morphologic characteristics include presence of Reed-Sternberg cells & lymphocyte-predominant cells
  • Divided into 2 types: Classic Hodgkin's lymphoma (CHL) & nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL)

Definition

  • A malignancy involving the lymph nodes & the lymphatic system

Etiology

  • Viruses (eg Epstein-Barr virus)
  • Positive family history of hematopoietic malignancy & autoimmune/chronic inflammatory diseases
  • Positive family history of Hodgkin's lymphoma

Prognostic Factors

  • Presence of the following reduces the survival rate by 7-8%/year
    • Age >45 years old
    • Gender - males are at increased risk
    • Patients diagnosed with stage IV disease
    • Albumin level: <4 g/dL
    • Hemoglobin (Hgb) level: <10.5 g/dL
    • Leukocytosis [White blood cell (WBC) >15,000/mm3]
    • Lymphocytopenia [Lymphocyte count <8% of white blood cell (WBC) &/or <600/mm3]

Signs and Symptoms

  • Assess patient’s performance status based on the clinical presentation
  • Painless peripheral adenopathies (commonly within the cervical or supraclavicular areas)
  • Chest pain or pain within the mediastinum
  • Pain at a nodal site after drinking alcohol
  • Chronic pruritus
  • Systemic B symptoms
    • Fever (>38oC/100.4oF)
    • Night sweats
    • Weight loss (>10% of baseline)
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Oncology - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Christina Lau, 13 Feb 2018

Combining gabapentin or pregabalin with opioid analgesics does not significantly improve cancer pain relief compared with opioid monotherapy, according to results of a recent systematic review and meta-analysis.

22 Jan 2018
In a symposium chaired by Dr Yoon-Sim Yap of the National Cancer Centre Singapore, renowned regional and international experts in the field of breast cancer, Dr Yen-Shen Lu from Taiwan and Professor Nadia Harbeck from Germany, joined her in providing insights on the current treatment landscape of hormone receptor-positive (HR+) advanced breast cancer. In their respective sessions, they each highlighted new therapeutic options including the optimal use of dual blockade therapy for oestrogenreceptor-positive (ER+) advanced breast cancer for patients in Asia.