herpes%20simplex%20virus%20infection
HERPES SIMPLEX VIRUS INFECTION
Primary herpes simplex virus (HSV) infection is first infection with either herpes simplex virus-1 (HSV-1) or herpes simplex virus-2 (HSV-2) in individuals who do not have antibodies to either HSV-1 or HSV-2.
First episode-non primary infection is infection with either HSV-1 or HSV-2 in individuals who have previously existing antibodies against HSV-1 or HSV-2 respectively.
Recurrent HSV infection results from reactivation of latent virus. It is usually brought about by triggering factors eg UV light, immunosuppression.
Orolabial HSV disease is mostly caused by HSV-1 that occurs most commonly in children <5 years of age. It is transmitted through close contact with individuals who have active viral shedding.
Genital HSV disease is caused by HSV-2 that is the usual cause of herpes genitalis. It typically occurs in adults and transmitted through sexual contact.

Definition

Primary Herpes Simplex Virus (HSV) Infection

  • 1st infection w/ either herpes simplex virus-1 (HSV-1) or herpes simplex virus-2 (HSV-2) in individuals who do not have antibodies to either HSV-1 or HSV-2

First Episode - Nonprimary Infection

  • Infection w/ either HSV-1 or HSV-2 in individuals who have previously existing antibodies against HSV-1 or HSV-2 respectively

Recurrent Herpes Simplex Virus (HSV) Infection

  • Results from reactivation of latent virus
  • Usually brought about by triggering factors (eg UV light, immunosuppression, trauma, stress, febrile illness)
  • Less severe & becomes less frequent w/ time
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Infectious Diseases - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pank Jit Sin, 02 May 2018
Leptospirosis is an endemic disease in Malaysia, but may be missed as doctors are not looking for it. 
Jairia Dela Cruz, 02 Oct 2018
Hepatitis D virus infection is highly prevalent in subgroups of individuals with intravenous drug use and those with high-risk sexual behaviour, study has reported. Its prevalence has also increased twofold over time in patients infected with hepatitis B virus.
07 Sep 2018
Children with Down syndrome appear to have an elevated risk of developing severe respiratory syncytial virus (RSV) infection, a study has found.
Dr. Joseph Delano Fule Robles, 14 Sep 2018

The nucleotide analogue tenofovir disoproxil fumarate (TDF) is associated with mild renal impairment in a minority of patients being treated for chronic hepatitis B virus (HBV) infection, a study by the Chinese University of Hong Kong (CUHK) has shown.