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HERPES SIMPLEX VIRUS INFECTION
Primary herpes simplex virus (HSV) infection is first infection with either herpes simplex virus-1 (HSV-1) or herpes simplex virus-2 (HSV-2) in individuals who do not have antibodies to either HSV-1 or HSV-2.
First episode-non primary infection is infection with either HSV-1 or HSV-2 in individuals who have previously existing antibodies against HSV-1 or HSV-2 respectively.
Recurrent HSV infection results from reactivation of latent virus. It is usually brought about by triggering factors eg UV light, immunosuppression.
Orolabial HSV disease is mostly caused by HSV-1 that occurs most commonly in children <5 years of age. It is transmitted through close contact with individuals who have active viral shedding.
Genital HSV disease is caused by HSV-2 that is the usual cause of herpes genitalis. It typically occurs in adults and transmitted through sexual contact.

Herpes Simplex Virus Infection References

  1. Drake S, Taylor S, Brown D, et al. Improving the care of patients with genital herpes. BMJ. 2000 Sep;321(7261):619-623. PMID: 10977846
  2. Colgan R, Michocki R, Greisman, et al. Antiviral drugs in the immunocompetent host: part I. Treatment of hepatitis, cytomegalovirus, and herpes infections. Am Fam Physician. 2003 Feb;67(4):675, 757-762. PMID: 12613729
  3. Emmert DH. Treatment of common cutaneous herpes simplex virus infection. Am Fam Physician. 2000 Mar;61(6):1697-1706, 1708. PMID: 10750877
  4. Yeung-Yue KA, Brentjens MH, Lee PC, et al. Herpes simplex viruses 1 and 2. Dermatol Clin. 2002 Apr;20(2):249-266. PMID: 12120439
  5. National guideline for the management of genital herpes. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). Sex Transm Infect. 1999 Aug(Suppl 1):S24-S28
  6. Centers for Disease Control and Prevention. Sexually transmitted disease treatment guidelines, 2006. MMWR Recomm Rep. 2006 Aug;55:1-94. PMID: 16888612
  7. Cernik C, Gallina K, Brodell RT. The treatment of herpes simplex infections: an evidence-based review. Arch Intern Med. 2008 Jun;168(11):1137-1144. doi: 10.1001/archinte.168.11.1137. PMID: 18541820
  8. Nath AK, Thappa DM. Newer trends in the management of genital herpes. Indian J Dermatol Venerol Leprol. 2009 Dec;75(6):566-574. doi: 10.4103/0378-6323.57716. PMID: 19915235
  9. Opstelten W, Neven AK, Eekhof J. Treatment and prevention of herpes labialis. Can Fam Physician. 2008 Dec;54(12):1683-1687. PMID: 19074705
  10. Kaye KM. Herpes simplex virus (HSV) infections. Merck Manual; 2013 May. http://www.merckmanuals.com/professional/infectious_diseases/herpesviruses/herpes_simplex_virus_hsv_infections.html. Accessed 16 Sep 2013
  11. MedWorm http://www.medworm.com/rss/index.php/Dermatology/12/ http://www.medworm.com/rss/medicalfeeds/specialities/Dermatology-News.xml
  12. MedWormhttp://www.medworm.com/rss/index.php/OBGYN/29/http://www.medworm.com/rss/medicalfeeds/specialities/OBGYN.xml
  13. Ministry of Health Malaysia. National antibiotic guideline 2014, 2nd edition. Pharmaceutical Services Divisions, Ministry of Health Malaysia. http://www.pharmacy.gov.my. Dec 2014. Accessed 16 Jul 2015.
  14. Patel R, Kennedy OJ, Clarke E, et al. 2017 European guidelines for the management of genital herpes. International Union Against Sexually Transmitted Infections (IUSTI). http://www.iusti.org. 2017. Accessed 29 May 2017.
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