Isolated hepatitis B core antibody (anti-HBc) positivity appears to increase the risk of liver-related and liver cancer mortality, particularly when accompanied by a high fibrosis score, according to a study of Korean adults.
Treatment with the dual PPAR α/γ agonist saroglitazar helps improve the serum atherogenic lipoprotein profile in patients with nonalcoholic fatty liver disease (NAFLD), regardless of comorbid conditions and statin use, as shown in a study.
The use of immune checkpoint inhibitors (ICIs) for the treatment of various cancers appears to have hepatotoxic effects, the risk of which is greater with ICI combination therapy than with monotherapy, as reported in a recent study.
Objective response to first-line systemic therapy with lenvatinib or sorafenib independently predicts overall survival (OS) in individuals with unresectable hepatocellular carcinoma (HCC), as shown by the subanalysis of the REFLECT study.
The risk of overall recurrent thrombosis (RT) is greater among individuals with idiopathic/local factor-related noncirrhotic splanchnic vein thrombosis (NC-SVT), reveals a study. Moreover, splanchnic RT can appear without symptoms and requires screening to be detected.
START-FIT, a prospective, single-arm, phase II trial, has foundsequential transarterial chemoembolization (TACE) and stereotactic body radiotherapy (SBRT) followed by anti–PD-L1 treatment with avelumab to be a promising strategy for making patients with locally advanced unresectable hepatocellular carcinoma (HCC) amenable to curative treatment.
Nonalcoholic fatty liver disease (NAFLD) screening strategies, particularly vibration-controlled transient elastography (VCTE) and fibrosis-4 (FIB-4), are a cost-effective approach to reduce disease burden among type 2 diabetes mellitus (T2DM) patients in Singapore, according to a study.
Treatment with albumin appears to cut the risk of death in cirrhotic patients with spontaneous bacterial peritonitis or hepatic encephalopathy, with long-term treatment potentially lowering the risk of cirrhosis complications and need for paracentesis, according to the results of a meta-analysis.