Hepatocellular carcinoma is malignancy that originates from the liver.

Physical signs are hepatomegaly and ascites. It is usually asymptomatic for much of its natural history.

Liver cancer is the second most common cause of cancer-related mortality worldwide & hepatocellular carcinoma accounts for >90% of liver cancers.


Hepatocellular%20carcinoma Management


  • Multiphasic cross-sectional imaging (eg CT or MRI) is the preferred method for surveillance following treatment due to its reliability in assessing arterial vascularity that is associated with increased risk of hepatocellular carcinoma recurrence following treatment
    • Test should be done every 3-6 months for 2 years, then every 6-12 months 
  • Serum alpha-fetoprotein (AFP) levels are associated with poor prognosis following treatment and should be measured every 3-6 months for 2 years, then every 6-12 months
  • In the event of disease recurrence, re-evaluation according to the initial work-up should be considered
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