Liver Transplantation
- Indicated in patients with end-stage liver disease (cirrhosis), hepatocellular carcinoma, and acute liver failure (ie caused by viruses, drugs and toxic agents)
- Considered in patients with expected survival of ≤1 year without transplantation or if quality of life is unsatisfactory due to the liver disease
- Patients with HBV infection should be evaluated for liver transplantation despite antiviral therapy as development of liver failure cannot be predicted
- Combination therapy with hepatitis B immunoglobulin and nucleos(t)ide analogues helps prevent HBV recurrence in these patients undergoing liver transplantation
- Recipient patients without anti-HBs should receive prophylaxis for HBV recurrence if transplanted liver is anti-HBc positive
- HDV replication is not a contraindication for liver transplantation