Treatment Guideline Chart

Hepatitis B is transmitted through perinatal, percutaneous, sexual, and close person-to-person contact, ie by open cuts and sores.

Human hepatitis B virus belongs to the family of Hepadnaviridae of small, enveloped, primarily hepatotropic DNA viruses. The virus replicates in the host and assembles exclusively in the hepatocytes and virions are released non-cytopathically through the cellular secretory pathway.

Chronic hepatitis B is defined as a chronic necroinflammatory liver disease due to persistent hepatitis B virus infection.

Hepatitis D infection is found only in patients with hepatitis B as it requires the hepatitis B outer coat. It is transmitted through sexual and percutaneous (especially IV drug use) routes.

Hepatitis B and D both have an incubation period of 30-180 days.

Hepatitis%20b Treatment

Hepatitis D - Pharmacological Therapy

  • Interferon alfa is the only approved chronic hepatitis D treatment and Peginterferon is the drug of choice 
    • Peginterferon alfa is recommended to be given for 48 weeks in patients with elevated ALT and HDV RNA levels  
  • Endpoint of therapy is the achievement of a complete virological response, ie undetectable HBsAg with sustained suppression of HDV RNA
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