Hepatitis A route of transmission is through oral-fecal route while in hepatitis E, aside from the oral-fecal route, it is also transmitted through blood transfusion in endemic areas.

Hepatitis A incubation period is 15-50 days and hepatitis E incubation period is 15-60 days.

Hepatitis A & E viruses cause epidemics.


Hepatitis%20a%20-and-%20e Treatment

General Care

Supportive Care

  • Consider hospitalization if there is vomiting, dehydration, signs of hepatic decompensation
  • Screen for other sexually-transmitted diseases (STDs) in cases of sexually acquired hepatitis or if otherwise appropriate

Hepatitis A

  • Supportive therapy is recommended; treatment for nausea and diarrhea should be given

Hepatitis E

  • Hepatitis E is a self-limiting disease and supportive therapy may be offered
  • Patients with severe acute hepatitis E or HEV-associated liver failure, or immunocompromised patients with chronic HEV may benefit from antiviral drugs (eg Ribavirin)
    • For immunocompromised patients with chronic HEV with persistent HEV detected by HEV RNA serum/stool testing after 12 weeks of Ribavirin treatment, additional 3 months monotherapy with Ribavirin may be considered
    • Pegylated interferon-α is a treatment option for liver transplant patients unresponsive to Ribavirin monotherapy
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