Helicobacter pylori is a spiral-shaped gram-negative bacterium involved in the development of gastritis, duodenal and gastric ulcers, and gastric cancer.
Infection is strongly associated with the development of gastric epithelial and lymphoid malignancies.
Acute infection is mostly asymptomatic and is acquired through human-to-human contact via gastro-oral and fecal-oral routes.
Adaptability in gastric conditions and production of urease allow it to colonize the stomach.
  1. Veldhuyzen van Zanten SJ, Flook N, Chiba N, et al. An evidence-based approach to the management of uninvestigated dyspepsia in the era of Helicobacter pylori. CMAJ. 2000 Jun;162(12 Suppl):S3-S23. PMID: 10870511
  2. Altintas E, Sezgin O, Ulu O, et al. Maastricht II treatment scheme and efficacy of different proton pump inhibitors in eradicating Helicobacter pylori. World J Gastroenterol. 2004 Jun;10(11):1656-1658. PMID: 15162544
  3. de Boer WA, Tytgat GN. Regular review: treatment of Helicobacter pylori infection. BMJ. 2000 Jan;320(7226):31-34. PMID: 10617524
  4. Goh KL. Update on the management of Helicobacter pylori infection, including drug-resistant organism. J Gastroenterol Hepatol. 2002 Apr;17(4):482-487. PMID: 11982731
  5. Goh KL, Mahendra R, Parasakthi N, et al. Management of Helicobacter pylori infection-a working party report of the Malaysian Society of Gastroenterology and Hepatology. Med J Malaysia. 1998 Sep;53(3):302-310. PMID: 10968173
  6. Kim SE, Park YS, Kim N, et al. Effect of Helicobacter pylori eradication on functional dyspepsia. J Neurogastroenterol Motil. 2013 Apr;19(2):233-243. doi: 10.5056/jnm.2013.19.2.233. Accessed 26 Jul 2013. PMID: 23667755
  7. Laine L, Shoenfeld P, Fennerty MB. Therapy for Helicobacter pylori in patients with nonulcer dyspepsia. A meta-analysis of randomized, controlled trials. Ann Intern Med. 2001 Mar;134(5):361-369. PMID: 11242496
  8. Lam SK, Talley NJ. Report of the 1997 Asia Pacific Consensus Conference on the management of Helicobacter pylori infection. J Gastroenterol Hepatol. 1998 Jan;13(1):001-12. PMID: 9737564
  9. Malekzadeh R, Mohamadnejad M, Siabvoshi F, et al. Treatment of Helicobacter pylori infection in Iran: low efficacy of recommended western regimens. Arch Iranian Med. 2004;7(1):001-8
  10. Malfertheiner P, Megraud F, O’Morain CA, et al. Management of Helicobacter pylori infection-the Maastricht IV/Florence Consensus Report. Gut. 2012 May;61(5):646-664. doi: 10.1136/gutjnl-2012-302084. PMID: 22491499
  11. Meurer LN, Bower DJ. Management of Helicobacter pylori infection. Am Fam Physician. 2002 Apr;65(7):1327-1336. PMID: 11996414
  12. Megraud F, Marshall BJ. How to treat Helicobacter pylori. First-line, second-line and future therapies. Gastroenterol Clin North Am. 2000 Dec;29(4):759-773. http://www.ncbi.nlm.nih.gov/pubmed/?term=11190062. PMID: 11190062
  13. Peterson WL, Fendrick A, Cave DR, et al. Helicobacter pylori-related disease: guidelines for testing and treatment. Arch Intern Med. 2000 May;160(9):1285-1291. http://www.ncbi.nlm.nih.gov/pubmed. PMID: 10809031
  14. Meyer JM, Silliman NP, Wang W, et al. Risk factors for Helicobacter pylori resistance in the United States: the surveillance of H. pylori antimicrobial resistance partnership (SHARP) study, 1993-1999. Ann Intern Med. 2002 Jan;136(1):13-24. PMID: 11777360
  15. Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s principles and practice of infectious diseases. 5th ed. Philadelphia: Elsevier Churchill Livingstone, Inc; 2000
  16. MedWormhttp://www.medworm.com/rss/index.php/Gastroenterology/17/http://www.medworm.com/rss/medicalfeeds/specialities/Gastroenterology.xml
  17. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  18. Sarbacker GB, Montfort E. Clinical considerations for the treatment of H pylori infection. US Pharmacist. http://www.uspharmacist.com. Dec 2011. Accessed 24 Jul 2013.
  19. Guidelines and Protocols Advisory Committee of British Columbia. Dyspepsia with or without Helicobacter pylori infection-clinical approach in adults. British Columbia Ministry of Health Services. http://www.bcguidelines.ca/. Dec 2009. Accessed 26 Jul 2013.
  20. Santacroce L, Miragliotta G, Bhutani MS. Helicobacter pylori infection. eMedicine. http://emedicine.medscape.com/. 2008.
  21. Chey WD, Wong BC; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007 Aug;102(8):1808-1825. http://s3.gi.org. PMID: 17608775
  22. Crowe SE. Treatment regimens for Helicobacter pylori. UpToDate. http://www.uptodate.com. 25 Apr 2014.
  23. Fock KM, Katelaris P, Sugano K, et al; Second Asia-Pacific Conference. Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection. J Gastroenterol Hepatol. 2009 Oct;24(10):1587-1600. doi: 10.1111/j.1440-1746.2009.05982.x. Accessed 03 Sep 2014. PMID: 19788600
  24. McColl KE. Clinical practice. Helicobacter pylori infection. N Engl J Med. 2010 Apr;362(17):1597-1604. doi: 10.1056/NEJMcp1001110. Accessed 03 Sep 2014. PMID: 20427808
  25. Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG clinical guideline: treatment of Helicobacter pylori infection. Am J Gastroenterol. 2017 Feb;112(2):212-239. doi: 10.1038/ajg.2016.563. PMID: 28071659
  26. Malfertheiner P, Megraud F, O'Morain CA, et al; European Helicobacter and Microbiota Study Group and Consensus panel. Management of Helicobacter pylori infection-the Maastricht V/Florence consensus report. Gut. 2017 Jan;66(1):6-30. doi: 10.1136/gutjnl-2016-312288. PMID: 27707777
  27. Crowe SE. Treatment regimens for Helicobacter pylori. UpToDate. https://www.uptodate.com. 20 Nov 2018.
  28. Graham DY, Dore MP. Update on the use of Vonoprazan: a competitive acid blocker. Gastroenterology. 2018 Feb;154(3):462-466. doi: 10.1053/j.gastro.2018.01.018. PMID: 29337157
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