Heart failure is a clinical syndrome caused by cardiac dysfunction usually secondary to myocardial muscle loss or dysfunction.
It is characterized by either left ventricular hypertrophy or dilation or both.
It leads to neurohormonal and circulatory abnormalities.
Acute heart failure is the rapid onset of or change in the signs and symptoms of heart failure.
It arises as a result of cardiac function deterioration in patients previously diagnosed with heart failure or may also be the first presentation of heart failure.
It is characterized by pulmonary congestion, decreased cardiac output and tissue perfusion.
It is a life-threatening condition that needs immediate medical attention.
The novel and selective SGLT2 inhibitor luseogliflozin does not seem to produce significant reductions in B‐type natriuretic peptide concentrations in patients with type 2 diabetes mellitus and heart failure with preserved ejection fraction (HFpEF) as compared with the alpha‐glucosidase inhibitor voglibose, according to data from the open‐label MUSCAT-HF trial.
In the treatment of patients with type 2 diabetes mellitus, both glucagon-like peptide-1 receptor agonists (GLP1-RAs) and sodium-dependent glucose cotransporter-2 inhibitors (SGLT2-Is) help lower blood pressure, improve glucose control without inducing weight gain, and confer cardio- and renoprotection, as shown in a study.
Patients with heart failure with reduced ejection fraction (HFrEF) who achieve 100 percent guideline-recommended target dose (GRTD) for both angiotensin-converting enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs) and β-blockers have a reduced risk of all-cause mortality and heart failure hospitalization (HHF), a recent study showed.
In the treatment of patients with heart failure with reduced ejection fraction (HFrEF), a comprehensive disease-modifying strategy combining four drugs—namely angiotensin receptor–neprilysin inhibitor (ARNI), β blocker, mineralocorticoid receptor antagonist (MRA), and sodium/glucose cotransporter 2 (SGLT2) inhibitor—yields incremental benefits that contribute to stopping or delaying clinical progression and extending survival, as shown in a study.
While the clinical risk factors for atrial fibrillation (AF) and its associated adverse outcomes are similar across ethnicities in Asia, AF is more common in some ethnic groups than the others, reveal the latest data from the ASIAN-HF* registry.
Patients with type 2 diabetes mellitus (T2DM) who are overweight or obese but have high cardiorespiratory fitness (CRF)* may have a reduced risk of heart failure (HF), according to a study presented at EPI Lifestyle 2020.
A novel, wearable heart failure (HF) patch accurately predicted worsening HF and impending rehospitalization days before the event actually happened in adults who were recently discharged from hospitalization for HF (HHF), according to the LINK-HF* study.
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.