Hand, foot and mouth disease (HFMD) is characterized by fever, vesicular stomatitis, and papular/vesicular lesions located peripherally (ie palms of hands, knees, soles of feet, buttocks or genitalia).
Oral vesicular lesions are 1-3 mm, mostly found on the buccal mucosa, tongue and soft palate.
Each oral lesion is surrounded by erythema and is tender to touch.
Patient may complain of sore throat or sore mouth, fever and may be difficult to feed.
Most common cause of HFMD is coxsackievirus A16 (A16).