Growth hormone deficiency in adults reflects an absence of two hormones, growth hormone and insulin-like growth factor-1 (IGF-1), affecting the process of glucose-insulin metabolism, lipolysis and bone remodelling.
History may show pituitary adenoma, surgery &/or radiation treatment of pituitary adenomas or cranial radiation for other disorders, deficiency of other pituitary hormones that may occur concurrently with growth hormone deficiency, and previous childhood growth hormone deficiency.
Physical exam reveals reduced lean body mass with increased weight, body fat predominantly in the abdominal region, thin & dry skin, cool peripheries, poor venous access and blunt affect.
Growth hormone (GH) replacement therapy increased left ventricular (LV) mass and improved metabolic parameters in prepubertal children with growth hormone deficiency (GHD), according to a study from Spain.
Asia's trusted medical magazine for healthcare professionals.
Get your MIMS Endocrinology - Malaysia digital copy today!
Undergoing in-facility physical activity (PA) programmes initiated before the 20th week of gestation helps reduce the risk of developing gestational diabetes mellitus (GDM) among high-risk mothers, according to the results of a meta-analysis.