Growth hormone deficiency is a congenital or an acquired growth hormone axis disruption in the higher brain, hypothalamus or pituitary which results in short stature.
It may occur at any age.
Short stature is often the only feature present in patients with growth hormone deficiency and other causes of subnormal growth rate.
Etiology may be congenital conditions (eg defective pituitary development that leads to pituitary aplasia, empty sella, encephalocele, midline defects) or acquired conditions (eg tumors of the hypothalamic-pituitary region, cranial irradiation, infiltrative disease).
Growth hormone therapy targets to reach the height in the population ranges. This study compared selected methods for predicting final height in Polish patients with severe (sGHD) and partial (pGHD) growth hormone deficiency.
Growth hormone deficiency (GHD) in paediatric and adult patients is treated with growth hormone (GH) therapy. Therapeutic goals, adverse reactions, and new delivery system were discussed in this review.
Individual patients may respond differently to growth hormone (GH) therapy, thus requiring close monitoring of the patients. This study compared data-driven approach with experience-based GH treatment.
Growth hormone (GH) has been recently approved for treatment of Prader-Willi Syndrome (PWS) and short stature homeobox-containing (SHOX) gene disorder under the public healthcare system, expanding previous indications that included GH deficiency, treatment of children with Turner syndrome and those with chronic renal failure before transplantation.
According to a randomised, controlled, multicentre, open-label study, growth hormone increases cortical bone thickness via endosteal bone growth in young adults with childhood-onset growth hormone deficiency (CO GHD).
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Among adolescents who have only received diphtheria, tetanus toxoids, acellular pertussis (DTaP) vaccines in childhood, tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine provides moderate protection against pertussis during the first year and then wanes rapidly thereafter.
Despite the prevalence of corticosteroid use in infants with bronchiolitis, data on its efficacy is insufficient. In this study, oral dexamethasone was compared with placebo in the treatment of bronchiolitis.