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graves'%20disease
GRAVES' DISEASE
Graves' disease is an autoimmune disorder that results into overproduction of thyroid hormones.
Thyrotoxicosis signs and symptoms include hyperactivity, irritability, insomnia, dysphoria, sweating, heat intolerance, palpitations, weakness, fatigue, weight loss despite increased appetite, diarrhea, steatorrhea polyuria, decreased libido, tachycardia, tremor, goiter, alopecia, gynecomastia, eyelid lag or retraction and rarely periodic paralysis.
Clinical features in thyrotoxic patient that suggests Graves's disease are ophthalmopathy, thyroid dermopathy, thyroid acropachy, diffuse goiter, antibodies to thyroid peroxidase or thyroglobulin and thyroid radionuclide scan demonstrating a diffuse goiter.

Graves'%20disease Signs and Symptoms

Definition

  • Thyrotoxicosis is a clinical state wherein there is an inappropriately high tissue thyroid hormone levels that results to increased thyroid hormone action in tissues
  • Hyperthyroidism is a form of thyrotoxicosis wherein the thyroid has an inappropriately high synthesis and secretion of thyroid hormones
  • Graves’ disease is a systemic autoimmune disorder in which thyrotropin receptor antibodies stimulate the thyroid stimulating hormone (TSH) receptor, increasing thyroid hormone production
    • Most common cause of hyperthyroidism

Signs and Symptoms

Thyrotoxicosis
  • Hyperactivity, irritability, insomnia, dysphoria
  • Sweating, heat intolerance
  • Palpitations
  • Weakness, fatigue
  • Weight loss with increased appetite
    • Weight gain may occur
  • Diarrhea, steatorrhea, polyuria
  • Decreased libido, oligomenorrhea
  • Tachycardia, atrial fibrillation in the elderly
  • Tremor
  • Goiter
  • Alopecia, gynecomastia
  • Eyelid lag or retraction
  • Rarely periodic paralysis (more often in Asian men)
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