Gout is a condition that resulted from deposition of monosodium urate crystals in various tissues (eg joints, connective tissue, kidney).
The patient experiences acute and chronic arthritis, soft tissue inflammation, tophus formation, gouty nephropathy and nephrolithiasis.
Primary hyperuricemia occurs when uric acid saturation arises without coexisting diseases or drugs that alter uric acid production or excretion, while secondary hyperuricemia is a condition where excessive uric acid production or diminished renal clearance occurs as a result of a disease, drug, dietary product or toxin.
The highly selective urate transporter 1 inhibitor SHR4640 has demonstrated superior serum uric acid (sUA)-lowering effect in Chinese patients with hyperuricaemia as compared with placebo, a phase II study has shown.
Using the urate-lowering drug febuxostat does not come with an excess risk of major cardiovascular (CV) events compared with allopurinol for gout treatment, according to the EMA*-mandated post-authorization safety study, FAST**.
In the treatment of patients with gout and hyperuricemia, use of febuxostat does not appear to come with an increased hazard of mortality or adverse cardiovascular (CV) outcomes, according to the results of a meta-analysis.
Higher serum uric acid (UA) levels appear to be protective against vertebral fracture among elderly men, whereas excessive reduction of serum UA using urate-lowering medications confers a risk increase, a study has shown.
Individuals with type 2 diabetes (T2D) who are prescribed an SGLT2* inhibitor may have a reduced risk for developing gout compared with those who are prescribed a GLP-1** receptor agonist, according to a study from the US.