Gout is a condition that resulted from deposition of monosodium urate crystals in various tissues (eg joints, connective tissue, kidney).
The patient experiences acute and chronic arthritis, soft tissue inflammation, tophus formation, gouty nephropathy and nephrolithiasis.
Primary hyperuricemia is called when uric acid saturation arises without coexisting diseases or drugs that alter uric acid production and excretion.
While in secondary hyperuricemia there is an excessive uric acid production or diminished renal clearance that occurs as a result of a disease, drug, dietary product or toxin.

Differential Diagnosis

  • Septic arthritis
    • It is important to rule out septic arthritis because if not diagnosed early, this can lead to rapid joint destruction associated with significant morbidity & mortality
    • Even if gout has already been confirmed with presence of MSU crystals, one should still check for septic arthritis because these inflammatory conditions may co-exist
  • Rheumatoid arthritis
  • Palindromic rheumatism
  • Reactive arthritis
  • Trauma
  • Pseudogout
  • Acute rheumatic fever
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