gastrointestinal%20stromal%20tumor
GASTROINTESTINAL STROMAL TUMOR
Gastrointestinal stromal tumors are morphologically spindle cell, epithelioid, or occasionally pleomorphic mesenchymal tumors of the gastrointestinal tract.
Signs and symptoms of gastrointestinal tumor include presence of abdominal mass (which may be an incidental finding in endoscopy), gastrointestinal bleeding, hemoperitoneum, anemia and gastrointestinal perforation.

Surgical Intervention

  • Complete surgical excision is the standard treatment of localized gastrointestinal stromal tumor (GIST)
    • Initial management of small GISTs <2 cm w/ high-risk endoscopic ultrasound (EUS) features
  • Wide local resection w/ 1- to 2-cm margin is done for most tumors
  • Tumors located in the colon may require hemicolectomy while tumors located in the rectum & anus will require abdominoperineal resection of the anus & rectum
  • Surgery may be warranted in unresectable or metastatic GIST if there is limited disease progression unresponsive to Imatinib or a locally advanced previously unresectable tumor which had a good response to Imatinib preoperatively

Preoperative Assessment

  • Computed tomography (CT) scan of the chest & abdomen should be done on all patients
    • Angiography performed if necessary (eg major vessels occluded by the tumor)
  • If large tumors are considered on the right or left upper quadrant of the abdomen, endocrine clearance should be done to exclude adrenal tumors
  • Alpha-fetoprotein (AFP) & beta-human chorionic gonadotropin (Β-hCG) levels should be determined in male patients w/ centrally placed tumors to exclude teratomas
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Gastroenterology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 5 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Stephen Padilla, 6 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
2 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 6 days ago
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.