Gastroesophageal reflux disease is a condition which results from the recurrent backflow of gastric contents into the esophagus and adjacent structures causing troublesome symptoms and/or tissue injury.
It is produced by various mechanisms such as frequent occurrence of transient relaxation of the lower esophageal sphincter or pressure abnormalities in the lower esophageal sphincter (which can be caused by hormonal and neural mediators, food, drugs and patient lifestyle).
Typical symptoms are acid regurgitation and heartburn.
Acid regurgitation is the perception of flow of refluxed gastric contents into the mouth or hypopharynx.
Heartburn is the burning sensation in the retrosternal region.
In the treatment of refractory gastroesophageal reflux-induced chronic cough (GERC), the lower oesophageal sphincter pressure (LESP) and lower oesophageal sphincter length (LESL) help predict baclofen efficacy, according to a study.
Transcutaneous electrical stimulation system is safe and has the potential to reduce oesophageal-acid exposure in patients with gastro-oesophageal reflux disease (GERD) unresponsive to proton pump inhibitor (PPI), as shown in a study.
Gastroesophageal reflux disease (GERD) may predispose patients to developing other diseases, as reported in a study. For the most part, it puts the whammy on chronic obstructive pulmonary disorder, doubling exacerbations, and raises the risk of oesophageal adenocarcinoma.