In paediatric patients with ulcerative colitis (UC), nonadherence to mesalazine negatively affects its therapeutic efficacy and may, in turn, result in treatment escalation, according to data from PROTECT.
Discontinuation of antitumour necrosis factor (anti-TNF) therapy for perianal Crohn’s disease is highly likely to lead to relapse, with some patients even requiring defunctioning surgery, according to a study conducted across Asia.
Treatment with the antitumour necrosis factor alpha appears to be beneficial in paediatric and adolescent patients with ulcerative colitis (UC), leading to lower colectomy rates within a period of 5 years and termination of corticosteroid use after 12 months, as shown in a recent study.
Patients with nonalcoholic fatty liver disease (NAFLD) may develop significant fibrosis in the absence of nonalcoholic steatohepatitis (NASH), with risk factors including fasting hyperglycaemia, severe steatosis, mild inflammation and the PNPLA3 I148M variant, according to a recent study.
Any manner of early postoperative diet delivered into the gastrointestinal tract (GIT) following colorectal surgery will help stimulate gut motility, leading to an earlier return of bowel function and a shorter length of hospital stay (LOS), according to a systematic review and meta-analysis.
A new class of orally administered drugs has been included in the armamentarium of treatment for ulcerative colitis (UC), according to a recent study, which reports the effectiveness of Janus kinase (JAK) inhibitors, particularly tofacitinib.
The PD-1* inhibitor nivolumab showed significant survival benefit and a favourable safety profile than taxane chemotherapy in patients with unresectable advanced or recurrent oesophageal squamous cell carcinoma (OSCC) refractory or intolerant to previous fluoropyrimidine- and platinum-based chemotherapy, according to the findings of ATTRACTION-3** presented at ESMO 2019.
Early enteral nutrition (EEN) speeds up the recovery of gastrointestinal function after laparoscopic common bile duct exploration (LCBDE), according to a study. However, EEN also increases complications such as diarrhoea and abdominal distension.
A third of Clostridium difficile infection (CDI) patients with cirrhosis have been readmitted in a span of 30 days primarily due to recurrent CDI, a recent study has found. In addition, there is a high rate of mortality linked to CDI in patients with cirrhosis, in which a poor prognosis is predicted by decompensation and 30-day readmission.