The PD-1* inhibitor nivolumab showed significant survival benefit and a favourable safety profile than taxane chemotherapy in patients with unresectable advanced or recurrent oesophageal squamous cell carcinoma (OSCC) refractory or intolerant to previous fluoropyrimidine- and platinum-based chemotherapy, according to the findings of ATTRACTION-3** presented at ESMO 2019.
Treatment with the novel acid secretion inhibitor vonoprazan at 10 mg effectively maintains remission through 52 weeks in patients with proton pump inhibitor (PPI)-resistant reflux oesophagitis, according to the results of a trial from Japan.
The use of tumour necrosis factor-α (TNFα) inhibitors was not associated with an increased risk of infection in children with inflammatory bowel disease (IBD), a contrast to previous findings in adult IBD, a study from Denmark showed.
Neither cobalamin intake nor age per se significantly predicts cobalamin status in community-dwelling older adults, a study has shown. Serum folate proves to be a significant predictor of serum cobalamin, whereas diseases such as cancer or inflammatory bowel disease (IBD) may influence cobalamin status.
Probiotic supplements, in addition to diet and exercise, may help obese children lose weight along with improvement in metabolic health compared with those undergoing lifestyle modification alone, according to a pilot study presented at the 58th Annual European Society for Paediatric Endocrinology (ESPE) Meeting held in Vienna, Austria.
Helicobacter pylori treatment for 2 weeks and vitamin or garlic supplementation for 7 years have significantly lowered the risk of death due to gastric cancer during 22.3 years of follow-up, according to a recent study. H pylori treatment and vitamin supplementation are also associated with a reduced incidence of gastric cancer.
Treatment with the combination of pinaverium bromide plus simethicone effectively relieves abdominal pain and bloating in patients with active irritable bowel syndrome (IBS), in addition to improving stool consistency in those with constipation-predominant IBS or a mixed bowel movement pattern, according to the results of a trial.
Mortality, length of stay (LOS) and hospital charges are significantly higher in chronic liver disease (CLD) patients with fractures, a recent study has shown. These findings are also associated with increased infection, bleeding and poorer wound healing.
New drug applications approved by US FDA as of 16 - 30 June 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.