Initial presenting symptoms do not differ between coronavirus disease (COVID-19) patients with and without gastrointestinal bleeding (GIB), a recent study has found. In addition, peptic ulcer disease and rectal ulcers from rectal tubes are the most common aetiology of those with upper and lower GIB, respectively.
Use of pegylated interferon alpha 2a as an add-on therapy in chronic hepatitis B patients on tenofovir disoproxil fumarate facilitates rapid reductions in hepatitis B surface antigen (HBsAg) and core-related antigen (HBcrAg) levels, a study has shown.
Inflammatory bowel disease (IBD) is associated with a heightened risk of urolithiasis both before and after diagnosis, a study has found. This association is especially pronounced in patients exposed to anti-tumour necrosis factor (anti-TNF) therapy and those who have undergone surgery, suggesting that IBD severity and surgery contribute to a risk increase.
In managing functional dyspepsia, itopride and acotiamide, tricyclic antidepressants, histamine‐2 receptor antagonists, proton pump inhibitors, and the antipsychotic sulpiride or levosulpiride all prove to be more effective than placebo, according to the results of a meta-analysis.
Reductions in liver fat and adipose tissue volumes were sustained in patients with type 2 diabetes (T2D) with the addition of the SGLT-2* inhibitor dapagliflozin (DAPA) and the DPP-4** inhibitor saxagliptin (SAXA) to metformin (MET), compared with a regimen comprising glimepiride (GLIM)+MET, according to the extension period results of a phase IIIb trial.