Individuals with high adherence to healthy dietary patterns, such as the alternate Mediterranean, Alternate Healthy Eating Index and Dietary Approaches to Stop Hypertension, are at low risk of developing symptomatic gallstone disease, a study has found.
There appears to be no greater early childhood gastrointestinal infections rates among adult individuals with irritable bowel syndrome (IBS) compared with adult controls, according to a study, which does not support a statistically significant association between early life infections and IBS aside from bronchitis.
Individuals with severe and frequent gastro-oesophageal reflux disease (GERD) are at increased risk of Barrett’s oesophagus (BE), especially in the absence of frequent proton pump inhibitor (PPI) use, a recent study has found. Family history of BE and early age of symptom onset are strong predictors of BE among people with GERD.
Complete resolution of nonalcoholic fatty liver disease (NAFLD) is highly likely to occur following sustained weight loss in obese patients who have undergone bariatric surgery, although there are still some who may develop new or worsened features of NAFLD, a study has shown.
In patients with genotype 3 hepatitis C virus (HCV) infection and decompensated cirrhosis, the rate of achieving sustained virologic response 12 weeks after treatment (SVR12) is high with treatment regimens consisting of sofosbuvir and velpatasvir with or without ribavirin, according to the results of a phase II trial. However, the rate appears to be lower in the subgroup of patients with baseline resistance-associated substitutions in nonstructural protein 5A.
Anxiety and depression appear to be more common in coeliac disease patients who have achieved mucosal healing than in those with persistent villous atrophy, both before and after follow‐up biopsy, a study has found. This association is potentially mediated by vigilant compliance with a gluten-free diet.
Vedolizumab is safe and effective in the treatment of inflammatory bowel disease (IBD) patients, according to a study. However, Crohn’s disease and a more severe disease appear to impair both short- and long-term effectiveness of the drug.
There has been an increase in use of topical 5-aminosalicylic acid (5-ASA) therapy in children and adolescents with ulcerative colitis (UC) in recent years, but the frequency of topical therapy use remains relatively low, particularly in patients with a more extensive disease, a recent study has shown.
Oral vitamin B-12 supplementation yields similar efficacy to that of hydroxocobalamin injections, according to a recent study. This suggests that oral supplementation can be used to replace hydroxocobalamin injections in the treatment of Roux-en-Y gastric bypass (RYGB) patients with low values of serum vitamin B-12.