Lubiprostone does not appear to have any favourable effect in the treatment of paediatric functional constipation (PFC), although the drug has a safety profile similar to that reported in adults, as shown in a phase III study.
The use of gastric acid-suppressive agents, such as proton pump inhibitors (PPIs) and histamine type-2 receptor antagonists (H2RAs) may aggravate the risk of dementia among patients with upper gastrointestinal disease, a recent Taiwan study has found.
Transcutaneous electrical stimulation system is safe and has the potential to reduce oesophageal-acid exposure in patients with gastro-oesophageal reflux disease (GERD) unresponsive to proton pump inhibitor (PPI), as shown in a study.
Women aged <40 years with alcohol-associated liver disease (ALD) remain at risk of mortality beyond 1 year after liver transplantation (LT), and the most common cause of death was recurrent disease or explicit mention of alcohol, a study has found.
Second-line chemotherapy may prolong the life of real-world patients with advanced biliary tract and gallbladder cancers and must therefore be provided to those who are potential candidates for chemotherapy, suggests a study.
While early-phase clinical trials may demonstrate substantial levels of overall response rates in patients with relapsed/refractory multiple myeloma (RRMM), high heterogeneity of evidence prevents the accurate assessment of clinical benefit before patient participation, reports a recent meta-analysis.
The COVID-19 vaccine AZD1222 by AstraZeneca and the University of Oxford was 79 percent effective overall in preventing symptomatic infections – higher than observed in previous clinical trials of the vaccine – at the interim analysis of a US phase III trial.
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.