Smoking duration is associated with the risk of developing colorectal polyps, according to a study. This relationship is stronger for distal rather than proximal polyps and for serrated polyps rather than adenomas, and is independent of smoking intensity and cessation and other potential confounders.
Twelve weeks of treatment with ledipasvir plus sofosbuvir may yield a sustained virologic response (SVR) of 100 percent in a group of patients coinfected with hepatitis C (HCV) and hepatitis B (HBV) viruses, as reported in a recent study. Most patients may have an increase in HBV DNA level that is not associated with signs or symptoms.
Adalimumab demonstrates continued safety and acceptability with long-term use in patients with moderately to severely active Crohn’s disease (CD) or ulcerative colitis (UC), without the emergence of new safety signals, a recent study has found.
Excessive and indiscriminate use of proton pump inhibitors (PPIs) may have perilous consequences for patients with chronic hepatitis C virus (HCV) infection, with a recent study showing that such pattern of exposure is associated with increased risks of progression of chronic liver disease to cirrhosis, hepatic decompensation and hepatocellular carcinoma.
The long-term presence of a large volume of acid refluxate appears to be a significant determinant of a reflux episode as chest pain (NCCP), a study has found. Furthermore, the presence of typical reflux symptoms raises the likelihood of reflux being involved in the generation of chest pain.
A mixture of the flavonoids diosmin, troxerutin, and hesperidin is safe and effective for the symptomatic management of patients with acute haemorrhoidal disease, a prospective, randomised, triple-blind, controlled trial revealed.