Progression-free (PFS) and overall survival (OS) are significantly lower in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib and concomitant gastric acid suppression therapy, a recent study has found.
Transjugular intrahepatic portosystemic shunt (TIPS) is superior to endoscopic band ligation (EBL) and other nonsurgical secondary prophylaxis interventions in reducing the incidence of cirrhosis oesophageal varices (EV) rebleeding, rebleeding-related mortality, and overall mortality in cirrhosis, results of a study have shown.
The three lymph node (LN) staging systems assessed in a recent study—the eighth TNM staging system, lymph node ratio (LNR, ratio between positive and total LN), and a new anatomic-based classification (Choi classification)—show comparable prognostic performance, but LNR-based classification better stratifies patients with resected gastric carcinoma (GC).
Bezlotoxumab is both safe and effective for the prevention of recurrent Clostridioides difficile infection (rCDI), results of a meta-analysis have shown. Moreover, bezlotoxumab may be a good therapeutic option for severe rather than mild CDI.
Updates from the SECURE-IBD* registry reveal that treatment with thiopurine, either alone or in combination with tumour necrosis factor inhibitors (TNFis), for inflammatory bowel disease (IBD) was associated with a greater risk of severe COVID-19 compared with TNFis monotherapy.