Laparoscopic adhesiolysis in carefully selected patients with chronic abdominal pain confers positive effect lasting beyond 15 years after surgery, according to a new study. However, various abdominal symptoms persist even as patients report pain relief.
In paediatric patients with Crohn’s disease (CD), using biologics within 3 months of diagnosis may help delay progression to stricturing and/or penetrating disease but not prevent early surgery, according to a study.
Exposure to antibiotics during pregnancy, but not in infantile age, appears to carry an increased risk of developing very early onset (VEO) inflammatory bowel disease (IBD) in children, as reported in a study from Sweden.
Primary sclerosing cholangitis (PSC) appears to be a strong and independent risk factor for advanced colorectal neoplasia (aCRN) in patients with colonic inflammatory bowel disease (IBD), with aCRN developing at a higher rate following detection of low-grade dysplasia (LGD) in IBD patients with PSC and is more often endoscopically invisible than in patients with only IBD, a study reports.
Alanine aminotransferase (ALT) flares are common during pregnancy and postpartum in previously treated women with chronic hepatitis B (CHB), particularly in those who discontinued antiviral therapy before pregnancy, during first trimester or at delivery, a recent study has found.
Measurement of serial alpha-fetoprotein (AFP) levels to evaluate biological response may help predict overall survival and intrahepatic remote recurrence after radiofrequency ablation (RFA), suggests a recent study.
Using simple noninvasive scores, a high prevalence of hepatic steatosis and advanced fibrosis has been detected in a large cohort of patients with type 2 diabetes mellitus (T2DM), reports a recent study.
During pregnancy, there is generalized relaxation of smooth muscle resulting in relaxa¬tion of the oesophageal sphincter, reduced gastric peristalsis, and delayed gastric emp¬tying. Small and large bowel transit times are increased. There is increased blood flow to the liver and increased production of fibrinogen, transferrin and many other binding proteins. Reference ranges for many liver function tests are altered. Gestation-specific alkaline phosphatase is increased, mainly from increased placental production, and aminotransferases and γ-glutamyltransferase are reduced.
New drug applications approved by US FDA as of 16 - 31 July 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.