ESMO World Congress on Gastrointestinal Cancer 2022

Tucatinib-trastuzumab combo induces durable tumour response in HER2+ mCRC

Elvira Manzano, 20220919000000

Dual HER-2 inhibition with tucatinib and trastuzumab induces clinically meaningful and durable responses in patients with previously treated metastatic HER2-positive colorectal cancer (mCRC) in the phase II MOUNTAINEER trial, boosting hopes for this chemotherapy-free combination.

Any upside to frontline mFOLFOXIRI-panitumumab in mCRC?

Roshini Claire Anthony, 20220914180001

In patients with unresectable RAS and BRAF wildtype metastatic colorectal cancer (mCRC), a modified FOLFOXIRI plus panitumumab (mFOLFOXIRI/PAN*) treatment strategy in the first-line setting did not improve objective response rate (ORR) compared with FOLFOX plus panitumumab (mFOLFOX6/PAN**), results of the phase III TRIPLETE study showed.

Pembrolizumab shows durable efficacy in sorafenib-treated advanced HCC

Christina Lau, 20220914021859

Pembrolizumab has demonstrated durable efficacy and a manageable adverse event (AE) profile in patients with advanced hepatocellular carcinoma (HCC) previously treated with sorafenib in a 5-year follow-up of the KEYNOTE-224 study.

STRIDE regimen benefit in unresectable HCC consistent across baseline liver function

Roshini Claire Anthony, 20220911100001

The overall survival (OS) benefit observed with the STRIDE regimen compared with sorafenib in patients with unresectable hepatocellular carcinoma (HCC) is consistent regardless of baseline liver function, according to exploratory analysis of data from the phase III HIMALAYA trial presented at ESMO GI 2022.

Second-line NIVO + IPI combo sustains response, OS benefit in aHCC

Elaine Soliven, 20220830000000

The combination of nivolumab 1 mg/kg (NIVO1) and ipilimumab 3 mg/kg (IPI3) every 3 weeks followed by NIVO 240 mg every 2 weeks in the second-line setting continues to confer durable response and overall survival (OS) benefit in patients with advanced hepatocellular carcinoma (aHCC), according to 5-year data from the CheckMate 040* trial presented at ESMO GI 2022.

Durvalumab + gemcitabine-cisplatin confers benefit in biliary tract cancer

Durvalumab + gemcitabine-cisplatin benefit in biliary tract cancer consistent across tumour locations

Roshini Claire Anthony, 20220827100001

The benefit of adding durvalumab to gemcitabine plus cisplatin chemotherapy in patients with advanced biliary tract cancer (BTC) was consistent regardless of primary tumour location, according to a subgroup analysis of the phase III TOPAZ-1 study presented at ESMO GI 2022.

First-line tislelizumab + chemo improves OS in advanced/metastatic ESCC

Elaine Soliven, 20220823000000

First-line treatment with tislelizumab + chemotherapy significantly improves overall survival (OS) in patients with advanced or metastatic oesophageal squamous cell carcinoma (ESCC) compared with chemotherapy alone, according to an interim analysis of the RATIONALE-306* trial presented at ESMO GI 2022.

RATIONALE-208 subanalyses boost tislelizumab potential for HCC

Audrey Abella, 20220805100000

The monoclonal antibody tislelizumab continued to show promise as a treatment alternative in certain subgroups of patients with previously treated advanced hepatocellular carcinoma (HCC), according to subgroup analyses of the phase II, single-arm RATIONALE-208 study.

Erlotinib + BSC fares better than BSC alone for gall bladder cancer

Audrey Abella, 20220803100000

The addition of erlotinib to best supportive care (BSC) provided better survival benefit than BSC only in individuals with unresectable/metastatic gall bladder cancer (GBC) with poor performance status (PS), according to a phase II/III open-label study.