Gastroenterology









Overall survival (OS) is currently the primary criteria in assessing the efficacy of a cancer treatment. Dr Raghav Sundar, a consultant medical oncologist at the National University Hospital, Singapore, details the crucial role played by tumour response in evaluating treatment efficacy, with a focus on the multiple kinase inhibitor lenvatinib in the treatment of hepatocellular carcinoma (HCC).

Advancements in genomics has paved the way for better classifications of colorectal cancers (CRC) and the use of precision therapy.





The addition of tremelimumab to durvalumab (STRIDE regimen) in the first-line setting improved overall survival (OS) compared with sorafenib in patients with advanced unresectable hepatocellular carcinoma (HCC), according to results of the phase III HIMALAYA trial.


Patients with advanced biliary tract cancer (BTC) who receive durvalumab in addition to standard of care (SoC) gemcitabine plus cisplatin chemotherapy in the first-line setting have a reduced risk of death compared with those receiving SoC alone, according to results of the TOPAZ-1 study presented at ASCO GI 2022.
