Gastroenterology

Top Medical News
High vitamin B6 status tied to better survival in stage I–III colorectal cancer
2 days ago
Higher preoperative vitamin B6 status appears to improve the overall survival (OS) of patients with stage I‒III colorectal cancer (CRC), suggests a recent study.
TNF-α antagonists superior to vedolizumab, ustekinumab for endoscopic healing in CD
Stephen Padilla, 2 days ago
The tumour necrosis factor-alpha (TNF-α) antagonist therapies adalimumab and infliximab are more effective than vedolizumab and ustekinumab in achieving endoscopic healing (EH) at 1 year among patients with moderate-to-severe Crohn’s disease (CD), a recent study has shown.
Gastric disease prevalence peaks during middle age, late adulthood
Tristan Manalac, 2 days ago
There appears to be a twin-peak prevalence profile (TPP) for diseases of the stomach, including Helicobacter pylori (Hp) infection, gastric cancer (GC), gastric intraepithelial neoplasia (GIN), and gastritis, according to a recent China study. The first peak typically occurs during middle-adulthood while the second peak happens in late life.
Artificial intelligence in colonoscopy promises better adenoma detection
Jairia Dela Cruz, 4 days ago
A real-time artificial intelligence (AI)-assisted colonoscopy device has the potential to improve the detection of polyps, including difficult-to-detect adenomas, even for experienced endoscopists, as shown in a study from Singapore.
Myocardial infarction after GI bleeding ups in-hospital mortality, resource use
5 days ago
A diagnosis of type 1 or type 2 myocardial infarction (MI) following hospitalization for gastrointestinal bleeding (GIB) often leads to higher in-hospital mortality and resource utilization, results of a recent US study have shown.
Semaglutide: Four STEPs ahead in obesity care
5 days ago
Obesity and metabolic comorbidities appear to be common among patients with large hepatocellular adenomas (HCAs) and adenomatosis, reports a study.
Tenofovir in mothers plus HBIG in infants best prevent vertical HBV transmission
5 days ago
For mothers with hepatitis B virus (HBV) infection who are positive for both hepatitis B surface and envelope antigens, administering a combination of hepatitis B vaccine and immunoglobulin (HBIG) in their infants plus tenofovir disoproxil fumarate (TDF) in the mothers themselves appears to be the best approach for preventing vertical disease transmission, according to a study.
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12 Mar 2021
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Relationship between tumour response to systemic therapy and overall survival in unresectable hepatocellular carcinoma
Dr Raghav Sundar, 09 Sep 2019

Overall survival (OS) is currently the primary criteria in assessing the efficacy of a cancer treatment. Dr Raghav Sundar, a consultant medical oncologist at the National University Hospital, Singapore, details the crucial role played by tumour response in evaluating treatment efficacy, with a focus on the multiple kinase inhibitor lenvatinib in the treatment of hepatocellular carcinoma (HCC).  

Role of genomics in colorectal cancers
Dr Joslyn Ngu, 04 Dec 2017

Advancements in genomics has paved the way for better classifications of colorectal cancers (CRC) and the use of precision therapy.

Conference Reports
CD-TREAT diet induces response/remission, improves QoL in patients with active CD
Elaine Soliven, 21 Jul 2022
CD-TREAT* diet, a food-based diet with a similar dietary profile to exclusive enteral nutrition (EEN), induces clinical response or remission and improves quality of life (QoL) in children and adults with active Crohn’s disease (CD), according to a study presented at ESPGHAN 2022.
Real-world studies demonstrate TAF efficacy and safety in chronic hep B
Roshini Claire Anthony, 20 Jul 2022

Treatment with tenofovir alafenamide (TAF) results in similar virological response compared with tenofovir disoproxil fumarate (TDF) in treatment-naïve patients with chronic hepatitis B (CHB), according to a real-world study from Korea presented at ILC 2022.

Resmetirom demos potential in NASH
Roshini Claire Anthony, 18 Jul 2022

Safety analysis of the phase III MAESTRO-NAFLD-1 trial presented at ILC 2022 demonstrated the potential of resmetirom as a treatment for patients with non-alcoholic steatohepatitis (NASH) who have liver fibrosis.

High-dose zinc intake tied to less feeding intolerance in VLBW infants
Elaine Soliven, 06 Jul 2022
High-dose zinc supplementation was significantly associated with decreased feeding intolerance in very low birth weight (VLBW) preterm infants, according to a study presented at ESPGHAN 2022.
Methotrexate proven safe, effective as first-line immunomodulator in paediatric CD
Stephen Padilla, 30 Jun 2022
Use of methotrexate (MTX) appears safe and effective as first-line immunomodulator for maintenance therapy in children with Crohn’s disease (CD), suggests a study presented at the 54th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN 2022).
Prucalopride offers relief in children with refractory idiopathic constipation
Jairia Dela Cruz, 28 Jun 2022
Three out of five teens with refractory constipation achieve improvements in bowel movement with prucalopride, while having acceptable side effect profiles, as shown in a small study.
Infliximab, adalimumab biosimilars effective, safe in paediatric IBD
Tristan Manalac, 27 Jun 2022
The use of biosimilars of infliximab (IFX) and adalimumab (ADA) is both safe and effective in children with inflammatory bowel disease (IBD), inducing high rates of failure-free survival with a low incidence of adverse events, according to a study presented at the 2022 Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN 2022).
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