Gastric cancer is the cancer originating in the esophagus, esophagogastric junction and stomach.
Most of gastric cancers are adenocarcinomas, subdivided according to histological appearances into diffuse (undifferentiated) and intestinal (well differentiated) types.
It is the 4th most common cancer and the 2nd most common cause of cancer-related deaths worldwide.
Most common sites of gastric cancer are the proximal lesser curvature, cardia and esophagogastric junction.
The oral formulation of paclitaxel, DHP107, shows promise in the second-line treatment of advanced gastric cancer (AGC), yielding progression-free survival (PFS) that is noninferior to that achieved with the intravenous formulation, with no significant differences in safety profiles, according to data from the DREAM III study.
Regular use of aspirin after eradication of Helicobacter pylori is found to reduce the risk of developing gastric cancer, according to a recent study by The University of Hong Kong (HKU). [J Natl Cancer Inst 2018, doi: 10.1093/jnci/djx267]
The addition of ramucirumab, a fully human IgG1 monoclonal antibody receptor antagonist, to chemotherapy, prolonged progression-free survival (PFS) in individuals with previously untreated metastatic gastric or gastroesophageal junction (G-GEJ) adenocarcinoma, findings from the phase III RAINFALL* trial show.
Individuals who have undergone gastrectomy for stomach cancer may have an added risk of developing tuberculosis (TB), according to a study from South Korea. However, this elevated risk does not appear to extend to nontuberculous mycobacteria (NTM) lung disease.
Indication and demand for genetic testing have increased in recent years, with tests becoming more readily available and affordable, says a leading oncologist at ESMO Asia 2017, highlighting that appreciation of ethical, social, and legal implications of testing and proper test interpretation are important for optimal patient management.
The Lauren classification can predict the differential benefits of fluoropyrimidine-based chemotherapeutics in intestinal (IGC) and diffuse (DGC) gastric cancer, a new study has shown. Specifically, adjuvant chemotherapy appears to not improve relapse-free survival (RFS) in DGC patients, opposite to its observed effects in IGC patients.
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.