Gastric cancer is the cancer originating in the esophagus, esophagogastric junction and stomach.
Most of gastric cancers are adenocarcinomas, subdivided according to histological appearances into diffuse (undifferentiated) and intestinal (well differentiated) types.
It is the 4th most common cancer and the 2nd most common cause of cancer-related deaths worldwide.
Most common sites of gastric cancer are the proximal lesser curvature, cardia and esophagogastric junction.
Neither gastric cancer nor gastric dysplasia is seen in patients with corpus atrophic gastritis (CAG) characterized at baseline with corpus pseudopyloric metaplasia (PPM) without corpus intestinal metaplasia (IM) because such lesions are consistently associated with corpus IM, reports a study.
Adding the VEGFR*-2 antagonist ramucirumab to paclitaxel extends survival of patients with advanced gastric/GEJ** adenocarcinoma compared with paclitaxel alone, regardless of liver metastasis status, according to a post hoc analysis of the RAINBOW*** trial presented at the ESMO GI 2021 Congress.
Anti-spike (anti-S) immunoglobulin G (IgG) antibody seropositivity rate in patients on active anticancer treatment remains high approximately 4 months after the second dose of the BNT162b2 mRNA coronavirus disease 2019 (COVID-19) vaccine, although median IgG titres are significantly lower than those in healthy individuals, a recent study has shown.
As a nutritional support, the amino acid-rich elemental diet does nothing to reduce the incidence of adverse events associated with receipt of docetaxel, cisplatin, and 5-fluorouracil-containing (DCF) chemotherapy in patients with oesophageal cancer, a study has found.
Targeted next-generation sequencing is useful for identifying genomic alterations in patients with gastric cancer and, in turn, should aid patient stratification for treatment optimization, according to a Singapore study.
Frequent consumption of spicy food appears to protect against the risk of gastrointestinal cancers, especially oesophageal cancer, and this association is pronounced among individuals who do not smoke and drink regularly, according to a study.
Gastroesophageal reflux disease (GERD) may predispose patients to developing other diseases, as reported in a study. For the most part, it puts the whammy on chronic obstructive pulmonary disorder, doubling exacerbations, and raises the risk of oesophageal adenocarcinoma.
Adding nivolumab to chemotherapy in the first-line setting significantly improves survival compared with chemotherapy alone in patients with HER2-negative advanced gastric/gastroesophageal (G/GEJ) cancer or oesophageal adenocarcinoma (EAC), shows the CheckMate 649 study presented at ESMO 2020.