Gastric cancer is the cancer originating in the esophagus, esophagogastric junction and stomach.
Most of gastric cancers are adenocarcinomas, subdivided according to histological appearances into diffuse (undifferentiated) and intestinal (well differentiated) types.
It is the 4th most common cancer and the 2nd most common cause of cancer-related deaths worldwide.
Most common sites of gastric cancer are the proximal lesser curvature, cardia and esophagogastric junction.
Not only does washing away free tumour cells in the peritoneum with extensive intraoperative peritoneal lavage (EIPL) during gastrectomy confer no survival benefit nor prevent disease recurrence compared with surgery alone, it may come with an increased risk of side effects, according to the phase III EXPEL* study presented at GICS 2020.
Neoadjuvant chemotherapy with S-1 and oxaliplatin (SOX) may be a suitable treatment measure for patients with advanced gastric or esophagogastric junction adenocarcinoma, according to the RESONANCE* trial presented at ASCO GI 2020.
Whether perioperative chemotherapy incorporating S-1 in the neoadjuvant setting provides better treatment outcomes than adjuvant chemotherapy postoperatively for patients with locally advanced gastric cancer (LAGC) was the topic of a lively discussion during the lunch forum session at the ISSPP 2019 Congress.
A neoadjuvant intraperitoneal and systemic chemotherapy (NIPS) comprising a triplet regimen of intraperitoneal docetaxel combined with intravenous cisplatin and oral S-1 was well tolerated with promising efficacy in patients who had gastric cancer with peritoneal carcinomatosis (PC), according to a presentation during the International Society for the Study of Pleura and Peritoneum (ISSPP) 2019 Congress held recently in Singapore
Helicobacter pylori treatment for 2 weeks and vitamin or garlic supplementation for 7 years have significantly lowered the risk of death due to gastric cancer during 22.3 years of follow-up, according to a recent study. H pylori treatment and vitamin supplementation are also associated with a reduced incidence of gastric cancer.
Individuals with type 2 diabetes mellitus (T2D) may be at risk of developing gastric cancer even after receiving Helicobacter pylori (H. pylori) eradication therapy, demonstrated a study from Hong Kong.
The combination of TAS-118 and oxaliplatin led to significantly greater survival compared with the S-1 and cisplatin combination in patients with metastatic or recurrent HER2-negative gastric cancer, the phase III SOLAR* study showed.
Pembrolizumab is noninferior to standard chemotherapy for overall survival (OS) in advanced gastric or gastroesophageal junction (G/GEJ) cancer in the first-line setting, thus providing a potential alternative treatment option for patients with G/GEJ, according to the KEYNOTE-062 study presented at ASCO 2019.
Whether patients had prior gastrectomy did not attenuate the survival benefit conferred by oral trifluridine/tipiracil for those with heavily pretreated metastatic gastric/gastroesophageal junction (G/GEJ) adenocarcinoma, according to new updates from the TAGS study presented at ASCO GI Cancers Symposium (GICS) 2019.
The combination of paclitaxel and FOLFOX led to an improvement in progression-free survival (PFS) compared with FOLFOX alone among chemotherapy-naïve patients with advanced gastric cancer, according to results from the phase II FNF-004* trial presented at ASCO GI 2019.
Use of adalimumab or infliximab in biologic-naïve patients with inflammatory bowel disease (IBD) delivers comparable rates of corticosteroid-free remission, as shown by a study presented at the Advances in Inflammatory Bowel Disease (AIBD) Conference 2019.