febrile%20neutropenia
FEBRILE NEUTROPENIA
Febrile neutropenia is having a fever of ≥38.3 ºC or ≥38 ºC over an hour and neutropenia that is having an absolute neutrophil count (ANC) of <500 neutrophils/mm3 or an ANC <1000 neutrophils/mm3 expected to decline to ≤500 neutrophils/mm3 over the next 48 hours.
The risk of febrile neutropenia is directly proportional to the duration and severity of neutropenia.
Fever is frequently the only indication of infection in the neutropenic patient.

Definition

Fever
  • Defined as single oral temperature ≥38.3 °C (101°F) or 2 consecutive readings ≥38.2 °C (100.4°F) over 1-2 hours
Neutropenia
  • Defined as an absolute neutrophil count (ANC) of ≤500/μL (<0.5 x 109/L) or an ANC ≤1000/μL expected to decline to ≤500/μL (<0.5 x 109/L) over the next 48 hours
  • Severe neutropenia is defined as ANC <500/μL (<0.5 x 109/L)
  • Profound neutropenia is defined as ANC <100/μL (<0.1 x 109/L)

The risk of febrile neutropenia is directly proportional to the duration and severity of neutropenia

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