febrile%20neutropenia
FEBRILE NEUTROPENIA
Febrile neutropenia is having a fever of ≥38.3 ºC or ≥38 ºC over an hour and neutropenia that is having an absolute neutrophil count (ANC) of <500 neutrophils/mm3 or an ANC <1000 neutrophils/mm3 expected to decline to ≤500 neutrophils/mm3 over the next 48 hours.
The risk of febrile neutropenia is directly proportional to the duration and severity of neutropenia.
Fever is frequently the only indication of infection in the neutropenic patient.

Definition

Fever
  • Defined as single oral temperature ≥38.3 °C (101°F) or 2 consecutive readings ≥38.2 °C (100.4°F) over 1-2 hours
Neutropenia
  • Defined as an absolute neutrophil count (ANC) of <500/μL (<0.5 x 109/L) or an ANC <1000/μL expected to decline to ≤500/μL (<0.5 x 109/L) over the next 48 hours
  • Severe neutropenia is defined as ANC <500/μL (<0.5 x 109/L)
  • Profound neutropenia is defined as ANC <100/μL (<0.1 x 109/L)

The risk of febrile neutropenia is directly proportional to the duration and severity of neutropenia

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Infectious Diseases - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Tristan Manalac, 19 Oct 2017
White matter (WM) integrity in HIV-infected children is compromised despite early antiretroviral therapy (ART) and viral load (VL) suppression, with damage persisting at 5 years of age and evidence of new damage present, a recent study has shown.
Tristan Manalac, 20 Feb 2020
Patients with Crohn’s disease (CD) seem to die at a younger age than people without inflammatory bowel disease (IBD), while those with ulcerative colitis (UC) die later, according to a recent study presented at the Crohn’s and Colitis Congress (CCC) 2020.