Epilepsy is a clinical multiaxial diagnosis.
Epileptic seizure is a transient occurrence of signs/symptoms brought about by abnormal excessive or synchronous neuronal activity in the brain.
It is recommended that all patients having a first seizure be referred as soon as possible to a specialist to ensure accurate and early diagnosis and initiation of treatment appropriate to the needs of the patients.
Use of eslicarbazepine acetate over the long term in the treatment of patients with focal epilepsy appears to be well tolerated and induces freedom from seizures, according to the results of an open-label study.
Stereotactic ablation using magnetic resonance imaging (MRI)–guided laser interstitial thermal therapy (MRg‐LITT) is well tolerated and improves outcomes for patients with extratemporal lobe epilepsy (ETLE), a study has shown. Treatment success is high among patients with lesional epilepsy and favourable seizure‐onset patterns.
For women with drug‐resistant focal epilepsy planning to conceive, undergoing surgery prior to pregnancy is the best option, with outcomes being more favourable than choosing to defer the procedure until after giving birth or opting for pharmacotherapeutic management, a study suggests.
Individuals with late-onset epilepsy appear to exhibit faster declines in global cognition, verbal memory, executive function, and word fluency over time compared with those who do not have the neurological disorder, and some of these declines occur prior to the index seizure, a study has found.
In the treatment of idiopathic generalized epilepsy, switching from valproate to other antiepileptic drugs due to potential childbearing issues may prove detrimental, heightening the risk of poor seizure control, as shown in a recent study.
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa,
08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.