Hyperinsulinaemia and insulin resistance appear to exacerbate phenotypic characteristics, reproductive endocrine disorders, and glucose and lipid metabolic dysfunction in polycystic ovary syndrome (PCOS) patients and therefore lead to reduced fertility in these women, a study has found.
New drug applications approved by US FDA as of 16 - 31 July 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
A home-based interval-walking programme markedly improves postprandial glycaemic control and reduces fat gain in treated patients with colorectal cancer, a study has shown. This strategy can potentially be used to help prevent secondary metabolic diseases.
Adjuvant radiotherapy (RT) following gross resection of adrenocortical carcinoma (ACC), a rare malignancy with high rates of recurrence and poor prognosis, results in better local recurrence-free survival (RFS), all RFS and overall survival, according to the results of a single-institution study.
Radiofrequency ablation (RFA) durably diminishes benign thyroid nodules and improves subjective symptoms of patients, making it a reliable alternative to surgery in the management of thyroid nodules, suggests a recent study.
A recent study suggests that instead of focusing on container or dishware size, reducing the number and variety of snack food items available appears to be a more effective intervention in preventing overconsumption of energy-dense foods and obesity in children.
Obesity at any age in adulthood doubles the risk of having poor physical functioning in midlife, with body mass index gains over much of the life course and prolonged exposure to obesity contributing to the risk, according to a study.
Progressive lipolysis may be reduced via the improved antilipolytic effect in adipose tissue, which leads to a reduction in future weight loss caused by sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes (T2D), suggests a recent study.
Maternal prepregnancy obesity is associated with earlier age at voice break, pubic hair development, axillary hair and acne in sons, as well as with earlier age at menarche, breast development, pubic hair development, axillary hair and acne in daughters, a study has found. These associations appear to be mediated by higher childhood body mass index in sons and partly so in daughters.