The coexistence of diabetes mellitus (DM) in Asian patients with heart failure (HF) who were receiving cardiac resynchronization therapy (CRT) attenuated CRT-induced left ventricular (LV) reverse modelling — a predictor of event-free survival — and was associated with worse clinical outcomes compared with patients without T2D, the PEACH* study shows.
A Mediterranean-based eating plan supplemented with extra-virgin olive oil helped delay the initiation of glucose-lowering medications among individuals with type 2 diabetes (T2D) controlled with lifestyle management, according to a subgroup analysis of the PREDIMED* trial.
Uric acid-lowering therapy for gout also confers benefits for hyperlipidaemia, with febuxostat delivering greater reductions in cholesterol and triglyceride concentrations in the blood as compared with allopurinol and benzbromarone, according to a recent study.
Metabolic syndrome (MetS) severity z-score independently predicts the incidence of diabetes in Asians, providing additional predictive information to individual MetS components and proving to be a stronger predictor than MetS, according to a Singapore study.
A single course of the Fc receptor–nonbinding anti-CD3 monoclonal antibody teplizumab appears to significantly reduce the speed of progression to clinical type 1 diabetes in high-risk, nondiabetic individuals, according to the results of the phase II Type 1 Diabetes TrialNet study.
Intensive glucose control for up to 72 hours was no better than standard therapy in terms of improving outcomes in hospitalized patients with hyperglycaemia and acute ischaemic stroke in the SHINE* trial, suggesting that intensive glucose control may not be useful in this setting.
About one-third of individuals who achieved remission of type 2 diabetes (T2D) after losing weight with an intensive weight management programme sustained their remission at 2 years, according to long-term results of the DiRECT* trial.
Progressive lipolysis may be reduced via the improved antilipolytic effect in adipose tissue, which leads to a reduction in future weight loss caused by sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes (T2D), suggests a recent study.
Maternal prepregnancy obesity is associated with earlier age at voice break, pubic hair development, axillary hair and acne in sons, as well as with earlier age at menarche, breast development, pubic hair development, axillary hair and acne in daughters, a study has found. These associations appear to be mediated by higher childhood body mass index in sons and partly so in daughters.
Long-term treatment with dual-release hydrocortisone (DR-HC) appears to produce favourable effects on insulin secretion and sensitivity in patients with prediabetes, according to a study. The treatment also confers benefits for metabolic and anthropometric parameters.