The glycated haemoglobin (HbA1c) test and oral glucose tolerance test (OGTT) appear to have low concordance for diagnosing prediabetes or diabetes in overweight or obese men and women, a recent study reports.
An association exists between greater insulin resistance (IR) and higher bone mineral density (BMD) in nondiabetic older adults, but evidence for an increased fracture risk with greater IR is inconsistent, a recent study has found.
Use of metreleptin for the treatment of patients with partial lipodystrophy is relatively safe and produces improvements in glycaemic control, hypertriglyceridaemia and liver volume, according to the results of an open-label study and its long-term extension phase.
About one-third of individuals who achieved remission of type 2 diabetes (T2D) after losing weight with an intensive weight management programme sustained their remission at 2 years, according to long-term results of the DiRECT* trial.
Progressive lipolysis may be reduced via the improved antilipolytic effect in adipose tissue, which leads to a reduction in future weight loss caused by sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes (T2D), suggests a recent study.
Maternal prepregnancy obesity is associated with earlier age at voice break, pubic hair development, axillary hair and acne in sons, as well as with earlier age at menarche, breast development, pubic hair development, axillary hair and acne in daughters, a study has found. These associations appear to be mediated by higher childhood body mass index in sons and partly so in daughters.
Long-term treatment with dual-release hydrocortisone (DR-HC) appears to produce favourable effects on insulin secretion and sensitivity in patients with prediabetes, according to a study. The treatment also confers benefits for metabolic and anthropometric parameters.