Use of antithyroid drug (ATD) therapy in early pregnancy appears to increase the risk of birth defects, suggesting that abnormal maternal thyroid function is not a major risk factor for birth defects, a recent study has shown.
Patients with metastatic adrenocortical carcinoma (ACC) appear to achieve modest benefits from treatment with nivolumab, as shown by results of a phase II trial. The safety profile of nivolumab is consistent with previous clinical experience with no unforeseen adverse events (AEs).
Low serum levels of total, low-density lipoprotein and high-density lipoprotein cholesterol contribute to an increased risk of developing Crohn’s disease, whereas low serum triglyceride levels increase susceptibility to ulcerative colitis, a recent study has shown.
Treatment with the neurokinin 3 receptor (NK3R) antagonist fezolinetant results in a quick and substantial decrease in moderate or severe vasomotor symptoms (VMSs), reports a phase IIa trial, highlighting its potential as an effective nonhormonal treatment option for menopausal women.
Overweight or obese women with gestational diabetes mellitus (GDM) may fare well with metformin treatment, which is reported in a recent study to safely and effectively prevent excessive and promote adequate gestational weight gain (GWG) independent of age, body mass index (BMI) and timing of GDM diagnosis, among others.
Incident hypertension is associated with hypertriglyceridemic waist-to-height ratio (HWHtR) and its dynamic status, according to a study of rural Chinese men. HWHtR may be used as a marker for interventions aiming to lower hypertension incidence in men.
Oily fish consumption confers a beneficial effect on serum triacylglycerol and high-density lipoprotein cholesterol (HDL-C) in a dose-dependent manner, but not on blood pressure (BP), heart rate variability (HRV) and glucose homeostasis, in children aged 8–9 years, according to a study.
An association exists between weight gain and a decrease in responsivity of regions connected to taste and reward processing to palatable high-fat and high-fat/high-sugar food tastes, a study has shown. Moreover, avoiding weight gain can increase the sensitivity of taste, which then helps prevent future excessive weight gain.
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Serum 25-hydroxyvitamin D (25[OH]D) levels are significantly lower among patients with active uveitis than those with inactive uveitis and local population-based estimates, reports a study. In addition, vitamin D supplementation may help reduce uveitis activity, while sun exposure confers a beneficial effect to those with vitamin D deficiency.
The timing of direct oral anticoagulants (DOACs) administration, either within 3 days or ≥4 days of stroke onset, in patients with nonvalvular atrial fibrillation (AF) does not alter the risk of adverse outcomes such as stroke or systemic embolism, major bleeding, and death, as shown in a recent study.