There appears to be a nonlinear relationship between total oestradiol and free oestradiol and all-cause mortality among older men, according to data from the Three-City cohort study. Specifically, the association is stronger for cardiovascular disease mortality and nonexistent for cancer mortality.
Small for gestational age (SGA) is independently associated with the development of delayed thyrotropin (also known as thyroid stimulating hormone [TSH]) elevation (dTSHe) among infants with a birthweight <2,000 g, according to a study.
Treatment with denosumab in postmenopausal women with osteoporosis for 2 and/or 3, 5, and 10 years, compared with placebo, correlates with normal histology, low bone remodelling rate, increased matrix mineralization and lower mineralization heterogeneity, a recent study has shown. Such variables persist from years 5–10.
Elevations in inflammatory protein levels in neonatal blood are associated with obesity among 2-year-old children born extremely premature, a study reports. This suggests that systemic inflammation contributes to the development of obesity.
Variations in albuminuria predict changes in renal risk among patients with hypertension and type 2 diabetes (T2D) under real-life clinical conditions, reports a study, suggesting that albuminuria status may help optimize therapeutic strategy.
Adolescents who sleep longer and have higher sleep efficiency have a favourable cardiometabolic profile, including lower abdominal adiposity, lower systolic blood pressure and higher high-density lipoprotein cholesterol levels, as shown in a study.
Canakinumab provides effective flare control and prevention in patients with monogenic autoinflammatory diseases, namely colchicine-resistant familial Mediterranean fever, mevalonate kinase deficiency and tumour necrosis factor receptor–associated periodic syndrome, according to the results of a phase III CLUSTER trial.
Individuals with severe obesity who undergo Roux-en-Y gastric bypass (RYGB) may have a higher risk of nonvertebral fractures than those who undergo adjustable gastric banding (AGB), according to a study presented at the recent ENDO 2018 sessions.
Calcium and vitamin D cosupplementation for eight weeks provided positive effects on biomarkers of inflammation and oxidative stress in a randomised double-blind placebo-controlled clinical trial among overweight and vitamin D-deficient women with polycystic ovarian syndrome.