Key tricarboxylic acid (TCA) cycle metabolites, in particular fumarate, are predictors of chronic kidney disease (CKD) progression in patients with type 2 diabetes (T2D), independent of traditional cardio-renal risk factors, suggests a recent study.
Plasma glucose levels at 1 hour of ≥8.6 mmol/L during an oral glucose tolerance test in obese children appear to be associated with hyperinsulinaemia, insulin resistance, elevated levels of interleukin 6 and visfatin, and reduced adiponectin, a study has found.
Electroretinogram-assessed localized retinal dysfunction in type 1 diabetes mellitus patients appears to occur even in the absence of clinical signs of diabetic retinopathy (DR), and this incidence is associated with ageing, according to a study.
Complete resolution of nonalcoholic fatty liver disease (NAFLD) is highly likely to occur following sustained weight loss in obese patients who have undergone bariatric surgery, although there are still some who may develop new or worsened features of NAFLD, a study has shown.
Zoledronate significantly reduces the risk of both nonvertebral and vertebral fragility fractures over 6 years in older women with osteopenia — a substantial patient group at risk for fractures but in whom a knowledge gap remains for pharmacological treatment, reveals a large randomized trial.