Diabetes mellitus (DM) is increasingly diagnosed in younger individuals. This poses challenges such as long exposure to diabetes and its complications and the need for tailor-made treatment protocols that fit a specific group of diabetic patients.
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In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.