Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.
Adding empagliflozin to recommended therapy in patients with heart failure with reduced ejection fraction (HFrEF) reduced the risk of HF hospitalization and slowed renal function decline, the EMPEROR-Reduced* trial showed.
An estimated 463 million adults – about one in 11 – had diabetes in 2019. These numbers are expected to rise to 700 million by 2045. Worse, one in two people are undiagnosed. [https://www.idf.org/, accessed 19 October 2020]
Ertugliflozin may be a suitable add-on therapy in patients with type 2 diabetes mellitus (T2DM) and established atherosclerotic cardiovascular disease (ASCVD) whose glucose levels are inadequately controlled by a metformin-sulfonylurea or insulin regimen, substudies of the phase III VERTIS* CV trial showed.
In patients hospitalized with COVID-19, hypernatraemia during hospitalization may increase mortality risk, while hyponatraemia at admission may up the need for ventilation support, a recent study from the UK showed.