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dyspepsia
DYSPEPSIA
Treatment Guideline Chart

Dyspepsia is having any one of the following: Disturbing postprandial fullness, early satiation, epigastric pain and/or burning felt predominantly in the upper abdomen.

It is considered a symptom complex rather than a specific diagnosis.

Acid suppression is the recommended initial therapy.

Dyspepsia References

  1. Delaney BC, Moayyedi P, Forman D. Initial management strategies for dyspepsia [abstract]. Cochrane Database Syst Rev. 2003(2):CD001961. PMID: 12804417
  2. Veldhuyzen van Zanten SJ, Flook N, Chiba N, et al. An evidence-based approach to the management of uninvestigated dyspepsia in the era of Helicobacter pylori. CMAJ. 2000 Jun;162(12 Suppl):S3-S23. PMID: 10870511
  3. Moayyedi P, Soo S, Deeks L, et al. Pharmacological interventions for non-ulcer dyspepsia [abstract]. Cochrane Database Syst Rev. 2003(1):CD001960. PMID: 12535421
  4. Schroeder BM. Evaluation of epigastric discomfort and management of dyspepsia and GERD. Am Fam Physician. 2003 Sep;68(6):1215-1220. PMID: 14524407
  5. Talley NJ. Dyspepsia: management guidelines for the millennium. Gut. 2002 May;50(Suppl 4):iv72-78. PMID: 11953354
  6. Simren M, Tack J. Functional dyspepsia: evaluation and treatment. Gastroenterol Clin North Am. 2003 Jun;32(2):577-599. PMID: 12858607
  7. Talley NJ, Vakil N; Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol. 2005 Oct;100(10):2324-2337. PMID: 16181387
  8. Talley NJ. Update on the role of drug therapy in non-ulcer dyspepsia. Rev Gastroenterol Disord. 2003;3(1):25-30. PMID: 12684590
  9. Talley NJ, Silverstein MD, Agréus L, et al. AGA technical review: evaluation of dyspepsia. Gastroenterology. 1998 Mar;114(3):582-595. PMID: 9496950
  10. Soll AH, Graham DY. Approach to the patient with dyspepsia and peptic ulcer disease. In: Yamada T, Alpers DH, Kalloo AN, eds. Principles of Clinical Gastroenterology. 1st. West Sussex; 2008.
  11. MedWormhttp://www.medworm.com/rss/index.php/Gastroenterology/17/http://www.medworm.com/rss/medicalfeeds/specialities/Gastroenterology.xml
  12. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  13. Scottish Intercollegiate Guidelines Network. Dyspepsia. A national clinical guideline. SIGN. http://www.guideline.gov. Mar 2003.
  14. National Institute for Health and Care Excellence. Dyspepsia: managing dyspepsia in adults in primary care. NICE. http://www.nice.org.uk. Aug 2004.
  15. North of England Dyspepsia Guideline Development Group. Dyspepsia: managing dyspepsia in adults in primary care: evidence-based clinical practice guideline. NICE. http://www.nice.org.uk/. Aug 2004.
  16. New Zealand Guidelines Group. Management of dyspepsia and heartburn: evidence-based practice guideline. Ministry of Health. http://www.health.govt.nz/. Jun 2004.
  17. Longstreth GF, Lacy BE. Approach to the adult with dyspepsia. UpToDate. http://www.uptodate.com/. 28 Aug 2013. Accessed 20 Jan 2014.
  18. Loyd RA, McClellan DA. Update on the evaluation and management of functional dyspepsia. Am Fam Physician. 2011;83(5):547-552. http://www.aafp.org/afp/2011/0301/p547.pdf. Accessed 20 Jan 2014. PMID: 21391521
  19. Miwa H, Kusano M, Arisawa T, et al; Japanese Society of Gastroenterology. Evidence-based clinical practice guidelines for functional dyspepsia. J Gastroenterol. 2015 Feb;50(2):125-139. doi: 10.1007/s00535-014-1022-3. PMID: 25586651
  20. Tack J, Camilleri M, Chang L, et al. Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther. 2012 Apr;35(7):745-767. doi: 10.1111/j.1365-2036.2012.05011.x. PMID: 22356640
  21. Wiśniowska B, Tylutki Z, Wyszogrodzka G, et al. Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials. BMC Pharmacol Toxicol. 2016 Mar 10;17:12. doi: 10.1186/s40360-016-0053-1. Accessed 27 Dec 2016. PMID: 26960809
  22. Stanghellini V, Chan FK, Hasler WL, et al. Gastroduodenal disorders. Gastroenterology. 2016 May;150(6):1380-1392. doi: 10.1053/j.gastro.2016.02.011. Accessed 28 Dec 2016. PMID: 27147122
  23. Espallardo NL, Guison-Bautista MTT, Alba-Concha ME, et al. Clinical pathways for the management of dyspepsia in family and community practice. The Filipino Family Physician. Jul-Sep 2017;55(3):130-142.
  24. Moayyedi PM, Lacy BE, Andrews CN, et al. ACG and CAG clinical guideline: management of dyspepsia. Am J Gastroenterol. 2017 Jul;112(7):988-1013. doi: 10.1038/ajg.2017.154. PMID: 28631728
  25. Longstreth GF, Lacy BE. Approach to the adult with dyspepsia. UpToDate. https://www.uptodate.com. 09 Dec 2019.
  26. Longstreth GF, Lacy BE. Functional dyspepsia in adults. UpToDate. https://www.uptodate.com. 16 Dec 2019.
  27. Ministry of Public Health Qatar. National Clinical Guideline: The assessment & management of dyspepsia (2020). Ministry of Public Health Qatar. https://www.moph.gov.qa. 28 Jul 2020.
  28. National Institute for Health and Care Excellence. Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management (CG184). NICE. http://www.nice.org.uk/guidance/cg184. Oct 2019.
  29. Oh JK, Kwon JG, Jung HK, et al. Clinical practice guidelines for functional dyspepsia in Korea. J Neurogastroenterol Motil. 2020 Jan 30;26(1):29-50. doi: 10.5056/jnm19209. PMID: 31917913
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