dyslipidemia
DYSLIPIDEMIA
Dyslipidemia is having an abnormal amount of lipids or fats in the blood.
Lipid profile is obtained from an individual with diabetes mellitus, coronary heart disease, cerebrovascular disease, peripheral arterial disease or other coronary heart disease risk factors or from an individual with family history or clinical evidence of familial hypercholesterolemia.
Plasma lipids are total cholesterol, high-density lipoprotein cholesterol, trigylcerides, and low-density lipoprotein cholesterol.
Evaluation of lipid profile must be performed in parallel with the risk assessment of coronary heart disease.

Definition

  • An abnormality in lipoprotein metabolism that results in elevations of low-density lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides, and/or non-high-density lipoprotein cholesterol (non-HDL-C) levels, or significantly reduced high-density lipoprotein cholesterol (HDL-C) levels
  • Increase in serum concentration of total cholesterol, LDL, triglycerides or non-HDL-C is equivalent to increased risk for cardiovascular diseases

Etiology

  • Depends on the type of dyslipidemia
  • Hereditary disorders associated with dyslipidemia include familial hypercholesterolemia, familial hypertriglyceridemia, familial combined hyperlipidemia, familial dysbetalipoproteinemia, chylomicronemia
  • Secondary causes include diabetes mellitus, diet, alcohol intake, hypothyroidism, renal failure, obstructive liver disease, Cushing’s syndrome, metabolic syndrome, medications (glucocorticoids, beta-blockers, thiazides, estrogen therapy)
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 11 Feb 2020

The consumption of processed meat or unprocessed red meat may be associated with a slightly elevated risk of incident cardiovascular disease (CVD)* and all-cause mortality, according to a US study.

29 Jan 2020
Several high-density lipoprotein (HDL) functionality parameters, which are linked to HDL roles on cholesterol metabolism, endothelial protection and antioxidant/anti-inflammatory defence, contribute to an increased risk of incident acute coronary syndromes and its manifestations in individuals at high risk of cardiovascular disease, a study reports.
Jairia Dela Cruz, 6 days ago
A wearable arrhythmia detection device, the AliveCor KardiaBand (KB), demonstrates moderate accuracy for diagnosing atrial fibrillation (AF) in comparison with a 12-lead electrocardiogram (ECG), as shown in a recent study. However, combining the automated device diagnosis with the electrophysiologists (EP) interpretation of unclassified readings improves overall accuracy.
Pearl Toh, 10 Feb 2020
Contrary to popular concern, use of statins was not associated with a greater decline in memory or cognition in the elderly over 6 years, according to data from the observational MAS*.