Dyslipidemia is having an abnormal amount of lipids or fats in the blood.
Lipid profile is obtained from an individual with diabetes mellitus, coronary heart disease, cerebrovascular disease, peripheral arterial disease or other coronary heart disease risk factors or from an individual with family history or clinical evidence of familial hypercholesterolemia.
Plasma lipids are total cholesterol, high-density lipoprotein cholesterol, trigylcerides, and low-density lipoprotein cholesterol.
Evaluation of lipid profile must be performed in parallel with the risk assessment of coronary heart disease.

Dyslipidemia References

  1. Jellinger PS, Smith DA, Mehta AE, et al; AACE Task Force for Management of Dyslipidemia and Prevention of Atherosclerosis. American Association of Clinical Endocrinologists' guidelines for management of dyslipidemia and prevention of atherosclerosis. Endocr Pract. 2012 Mar;18(Suppl 1):1-78. https://www.ncbi.nlm.nih.gov. Accessed 4 Sep 2013. PMID: 22522068
  2. Choice of lipid-regulating drugs. Med Lett Drugs Ther. 2001 May;43(1105):43-48. PMID: 11378632
  3. American Diabetes Association. Standards of medical care in diabetes - 2011. Diabetes Care. 2011 Jan;34(Suppl 1):S11-S61. PMID: 21193625
  4. Baldassarre D, Franceschini G, Peruzzotti G, et al. Clinical evaluation of probucol in hypercholesterolemia: individual lipoprotein responses & inhibitory effect on carotid atherosclerosis progression [abstract]. J Cardiovasc Pharmacol. 1997 Dec;30(6):784-789. PMID: 9436818
  5. Bhatnagar D, Soran H, Durrington PN. Hypercholesterolaemia and its management. BMJ. 2008 Aug;337:a993. PMID: 18719012
  6. Bruckert E, Giral P, Tellier P. Perspectives in cholesterol-lowering therapy: the role of ezetimibe, a new selective inhibitor of intestinal cholesterol absorption. Circulation. 2003 Jul;107(25):3124-3128. PMID: 12835406
  7. Cybulska B, Szostak WB, Podolec P, et al. Polish forum for prevention guidelines on dyslipidemia. Kardiol Pol. 2008 Nov;66(11):1239-1242. PMID: 19105106
  8. Cacoub P, Tocque-Le Gousse E, Fabry C, et al. Application in general practice of treatment guidelines for patients with dyslipidaemia: the RESPECT study. Arch Cardiovasc Dis. 2008 Nov;101:715-721. PMID: 19059566
  9. Dos Santos JE, loures-Vale AA, Novazzi JP, et al. Evaluation of efficacy & safety of etofibrate in primary hyperlipidemia. A multicenter study [abstract]. Arq Bras Cardiol. 1996 Dec;67(6):419-422. PMID: 9246832
  10. Fletcher B, Berra K, Ades P, et al. Managing abnormal blood lipids: a collaborative approach. Circulation. 2005 Nov;112(20):3184-3209. PMID: 16286609
  11. Ferdowsian HR, Barnard ND. Effects of plant-based diets on plasma lipids. Am J Cardiol. 2009 Oct;104(7):947-956. PMID: 19766762
  12. Grundy SM, Cleeman JL, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation. 2004 Jul;110(2):227-239. PMID: 15249516
  13. Gupta EK, Ito MK. Ezetimibe: the first in a novel class of selective cholesterol-absorption inhibitors. Heart Dis. 2002 Nov;4(6):399-409. PMID: 12441019
  14. Jellinger PS, Dickey RA, Ganda OP, et al; AACE Lipid Guidelines Committee. The American Association of Clinical Endocrinologists. AACE medical guidelines for clinical practice for the diagnosis and treatment of dyslipidemia and prevention of atherogenesis. Endocr Pract. 2000 Mar;6(2):162-213. PMID: 11428356
  15. European Association for Cardiovascular Prevention & Rehabilitation, Reiner Z, Catapano AL, et al. ESC/EAS guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias for the European Association Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J. 2011 Jul;32(14):1769-1818. doi: 10.1093/eurheartj/ehr158. PMID: 21712404
  16. Reiner Z. Combined therapy in the treatment of dyslipidemia. Fundam Clin Pharmacol. 2010 Feb;24(1):19-28. PMID: 19682080
  17. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. Euro Heart J. 2007 Jan;28(1):88-136. http://www.escardio.org. PMID: 17220161
  18. Braunwald E, Zipes DP, Libby P. Risk for atherosclerotic disease. Heart disease: a textbook of cardiovascular medicine. 6th ed. Philadelphia: W.B. Saunders Company; 2001:1010-1022
  19. MedWormhttp://www.medworm.com/rss/index.php/Cardiology/7/http://www.medworm.com/rss/medicalfeeds/specialities/Cardiology.xml
  20. MedWormhttp://www.medworm.com/rss/index.php/Endocrinology/15/http://www.medworm.com/rss/medicalfeeds/specialities/Endocrinology.xml
  21. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  22. Academy of Medicine of Malaysia, Ministry of Health of Malaysia. Clinical practice guidelines on dyslipidaemia. 3rd ed. Academy of Medicine of Malaysia Web Site. http://www.acadmed.org.my/. Aug 2003.
  23. Ministry of Health Singapore. Clinical practice guidelines: lipids. MOH (Singapore). http://www.moh.gov.sg.cpg. 2006
  24. National Heart Association of Malaysia, Ministry of Health and the Academy of Medicine Expert Panel. CPG in management of dyslipidaemia. National Heart Association of Malaysia website. http://www.malaysianheart.org/. 2011. Accessed 26 Jul 2011.
  25. American Dietetic Association. Disorders of lipid metabolism. Evidence-based nutrition practice guideline (executive summary). Academy of Nutrition and Dietetics website. http://www.andeal.org/. 2011.
  26. Institute for Clinical Systems Improvement (ICSI). ICSI health care guideline: lipid management in adults. 10th ed. Institute for Clinical Systems Improvement (ICSI) website. http://www.icsi.org. 2007.
  27. National Institute for Health and Care Excellence. Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease. NICE clinical guideline 67. NICE. http://www.nice.org.uk/. May 2008.
  28. Philippine Heart Association. The clinical practice guidelines for the management of dyslipidemia in the Philippines [executive summary]. http://www.philheart.org/. Dec 2005.
  29. International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome. International Diabetes Federation website. http://www.idf.org/. Apr 2005.
  30. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. http://www.nhlbi.nih.gov.
  31. MedWorm - Cholesterolhttp://www.medworm.com/rss/medicalfeeds/conditions/Cholesterol-News.xml
  32. Berglund L, Brunzell JD, Goldberg AC, et al. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012 Sep;97(9):2969-2989. doi: 10.1210/jc.2011-3213. Accessed 04 Sep 2013. PMID: 22962670
  33. Eckel RH, Jakicic JM, Ard JD, et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines. Nov 12, 2013. Circulation. 2014 Jun;129(25)(Suppl 2). doi: 10.1161/01.cir.0000437740.48606.d1. PMID: 24222015
  34. Goff DC Jr, Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014 Jun;129(Suppl 2):S49-S73. doi: 10.1161/01.cir.0000437741.48606.98. PMID: 24222018
  35. Stone NJ, Robinson J, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2013 Nov;129(25)(Suppl 2):S1-S45. doi: 10.1161/01.cir.0000437738.63853.7a. Accessed 28 Mar 2014. PMID: 24222016
  36. Safi SZ, Qvist R, Kumar S, et al. Molecular mechanisms of diabetic retinopathy, general preventive strategies, and novel therapeutic targets. Biomed Res Int. 2014;2014:801269. doi: 10.1155/2014/801269. PMID: 25105142
  37. Ministry of Health Malaysia, Malaysian Society of Ophthalmology & Academy of Medicine Malaysia. Clinical practice guidelines on screening of diabetic retinopathy. Academy of Medicine of Malaysia. http://www.acadmed.org.my. Jun 2011.
  38. Guerrero AE, Gonzalez-Santos LE, Caole-Ang IV, et al. 2015 Updated clinical practice guidelines for the management of dyslipidemia in the Philippines. Philippine Society of Endocrinology, Diabetes and Metabolism. http://endo-society.org.ph. 2015. Accessed 03 Aug 2016.
  39. Writing Committee, Lloyd-Jones DM, Morris PB, et al. 2016 ACC expert consensus decision pathway on the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk: a report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 2016 Jul 5;68(1):92-125. doi: 10.1016/j.jacc.2016.03.519. PMID: 27046161
  40. Anderson TJ, Grégoire J, Pearson GJ, et al. 2016 Canadian Cardiovascular Society guidelines for the management of dyslipidemia for the prevention of cardiovascular disease in the adult. Can J Cardiol. 2016 Nov;32(11):1263-1282. doi: 10.1016/j.cjca.2016.07.510. PMID: 27712954
  41. Jellinger PS, Handelsman Y, Rosenblit PD, et al. American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of dyslipidemia and prevention of atherosclerosis. Endocr Pract. 2017 Feb. doi: 10.4158/EP171764.GL. PMID: 28156151
  42. Lloyd-Jones DM, Morris PB, Ballantyne CM, et al. 2016 ACC expert consensus decision pathway on the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk: a report of the American College of Cardiology Task Force on clinical expert consensus documents. J Am Coll Cardiol. 2016 Jul;68(1):92-125. doi: 10.1016/j.jacc.2016.03.519. PMID: 27046161
  43. Siscovick DS, Barringer TA, Fretts AM, et al; American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Epidemiology and Prevention; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology. Omega-3 polyunsaturated fatty acid (Fish Oil) supplementation and the prevention of clinical cardiovascular disease: a science advisory from the American Heart Association. Circulation. 2017 Mar. doi: 10.1161/CIR.0000000000000482. PMID: 28289069
  44. Catapano AL, Graham I, De Backer G, et al; Authors/Task Force Members; Additional Contributor. 2016 ESC/EAS guidelines for the management of dyslipidaemias. Eur Heart J. 2016 Oct;37(39):2999-3058. doi: 10.1093/eurheartj/ehw272. PMID: 27567407
  45. Ministry of Health Singapore. MOH clinical practice guidelines on lipids. Ministry of Health Singapore website. https://www.moh.gov.sg. Dec 2016.
  46. Rosenson RS. Lipoprotein classification, metabolism, and role in atherosclerosis. UptoDate website. https://www.uptodate.com/. Jun 2015.
  47. Semenkovich CF, Goldberg AC, Goldberg IJ. Disorders of lipid metabolism. In: Melmed S, Polonsky KS, Larsen, PR, Kronenberg HM. Williams Textbook of Endocrinology. 13th ed. Philadelphia, PA: Elsevier Inc; 2016:1660-1700.
  48. Vijan S. Screening for lipid disorders in adults. UptoDate website. http://www.uptodate.com/. Dec 2016.
  49. Cheung BM, Cheng CH, Lau CP, et al. 2016 Consensus statement on prevention of atherosclerotic cardiovascular disease in the Hong Kong population. Hong Kong Med J. 2017 Apr;23(2):191-201. doi: 10.12809/hkmj165045. Accessed 01 Aug 2017. PMID: 28387202
  50. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2017 Nov 7:pii: S0735-1097(17)41519-1. doi: 10.1016/j.jacc.2017.11.006. Accessed 16 Nov 2017. PMID: 29146535
  51. Ministry of Health Malaysia, Academy of Medicine Malaysia, National Heart Association of Malaysia. 5th Edition of clinical practice guidelines on management of dyslipidaemia 2017. http://www.acadmed.org.my. 2017.
  52. American Family Physician. U.S. Preventive Services Task Force screening for lipid disorders in adults: Recommendation Statement. Am Fam Physician. 2009 Dec 1;80(11):1273-1274. https://www.aafp.org.
  53. Alshamiri M, Ghanaim MMA, Barter P, et al. Expert opinion on the applicability of dyslipidemia guidelines in Asia and the Middle East. Int J Gen Med. 2018 Jul 18;11:313-322. doi: 10.2147/IJGM.S160555. PMID: 30050317
  54. Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the management of blood cholesterol: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018 Nov 3. pii: S0735-1097(18)39033-8. doi: 10.1016/j.jacc.2018.11.002. Accessed 29 Jan 2019. PMID: 30423391
  55. Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. ESC. http://www.escardio.org. 31 Aug 2019. Accessed 9 Sep 2019.
  56. Nordestgaard, BG, Chapman MJ, Humphries SE, et al. Familial Hypercholesterolemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J. 2013 Dec;34(45):3478-3490a. doi: 10.1093/eurheartj/eht273. PMID: 23956253
  57. Rosenson RS, Durrington P. Familial hypercholesterolemia in adults: overview. UpToDate. www.uptodate.com. 2019 Apr.
  58. Rosenson RS, Durrington P. Familial hypercholesterolemia in adults: treatment. UpToDate. www.uptodate.com. 2019 Nov.
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