Diabetic retinopathy is an abnormality of the microvasculature of the retina that occurs to almost all patients with chronic diabetes mellitus.
It is one of the leading cause of blindness worldwide and principal cause of impaired vision in patients aged 25-75 years of age.
The abnormality causes microaneurysms, retinal hemorrhages, lipid exudates, macular edema & neovascular vessel growth that may lead to blindness.
Unintentional treatment interruptions in diabetic retinopathy patients, especially those with proliferative disease, managed with antivascular endothelial growth factor (anti-VEGF) therapy alone can result in irreversible blindness, as shown in a recent study.
Diabetic retinopathy is a leading cause of blindness, making early detection of this condition crucial. Dr Yong Shao Onn from the Eagle Eye Centre at Mt Alvernia Hospital, Singapore, speaks to Roshini Claire Anthony on the diagnosis and treatment options.
Intra-individual variability in serum creatinine levels and estimated glomerular filtration rate (eGFR) over 3 years was independently associated with the presence as well as the severity of diabetic retinopathy (DR) in patients with type 2 diabetes (T2D), indicating that variability in these biomarkers can serve as predictors to identify T2D patients at risk of DR, suggests a local study.
In the treatment of proliferative diabetic retinopathy (DR), eyes gain vision and rarely develop vision-impairing central-involved diabetic macula oedema (DME) over 2 years with ranibizumab, according to a posthoc analysis. In contrast, factors such as poor glycaemic control and more severe DR increase the likelihood of losing visual acuity and developing DME following panretinal photocoagulation (PRP).
Administering intravitreal injections of ranibizumab in addition to panretinal photocoagulation (PRP) appears to be more effective than PRP monotherapy in terms of neovascularization regression in patients with high-risk proliferative diabetic retinopathy, according to a study.
Individuals who have a higher perception of barriers to diabetes self-management may be at an elevated risk for diabetic retinopathy (DR), according to findings of the Singapore Diabetes Management Project study.
Individuals with diabetic retinopathy (DR) appear to have thicker macula and outer retina compared with those who do not have the diabetic eye disease, and such thickening is more pronounced in eyes with severe DR, according to a study.
Individuals with mild-to-moderate non-proliferative diabetic retinopathy appear to have an elevated risk of falls compared with individuals with diabetes but no diabetic retinopathy, according to a Singapore study.
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Men who use calcium channel blockers (CCBs) are at risk of developing prostate cancer, and the risk increases with the duration of CCB exposure, according to the results of a systematic review and meta-analysis.
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.