Diabetes mellitus (DM) is a heterogenous metabolic disorder characterized by the presence of hyperglycemia with carbohydrate, protein and fat metabolism disturbance which results from defects in either insulin secretion or action.
Patients with DM usually present with polyuria, polydipsia and unexplained weight loss.
Type 1 DM is caused by beta cell destruction which leads to complete insulin deficiency. It may be immune mediated or idiopathic.
Patients may present with ketoacidosis or acute onset of hyperglycemia while other patients may resemble type 2 DM or symptoms of other autoimmune disorders.
Type 2 DM is the most common form of diabetes. It is secondary to defect in insulin secretion concomitant with insulin resistance.
Majority of patients are asymptomatic. Ketoacidosis is uncommon and is usually secondary to stress (eg infection).
Using a composite score of four blood biomarkers may be useful for predicting the risk of type 2 diabetes (T2D) in a Chinese population, suggests the nested case-control analysis of the Singapore Chinese Health Study (SCHS).
Use of a closed-loop system, also known as the artificial pancreas, led to better glycaemic control in terms of more time spent in the target glycaemic range than a sensor-augmented insulin pump in patients with type 1 diabetes (T1D), according to the iDCL* study.
Patients with chronic obstructive pulmonary disease (COPD) who initiate treatment with inhaled corticosteroids (ICS) may have an elevated risk of developing type 2 diabetes mellitus (T2DM), according to a matched cohort study.
Oral form of the GLP-1* analogue semaglutide was superior to the SGLT-2i** empagliflozin in reducing HbA1c in patients with type 2 diabetes (T2D) uncontrolled on metformin, according to the head-to-head PIONEER 2*** trial.
Duodenal mucosal resurfacing proves to be a feasible and safe endoscopic procedure in type 2 diabetes (T2D) patients with suboptimal response to oral glucose-lowering medications, conferring durable improvements in glycaemic parameters and liver transaminase levels, as shown in a study.
The use of thiazides appears to contribute to an increased risk of stroke in patients with type 2 diabetes, specifically in those receiving intensive blood pressure (BP) control, a recent study has found.
Singapore seems to be moving in the right direction with its “War on Diabetes” (WoD) initiative implementing preventive practices that target modifiable risk factors among middle-aged people, according to a study. However, while a number of Singaporeans has since made positive lifestyle changes, most still log insufficient physical activity and have suboptimal diet practices.
Large decreases in glycaemic level potentially represent a red flag for dementia in older adults with type 2 diabetes, suggesting that optimizing glycaemic level in later life requires caution, according to a recent study.
Taisho Pharmaceutical launches Lusefi®, an oral anti-diabetic medication for type 2 diabetes mellitus (T2DM). The medication is expected to lower blood glucose and provide adequate glycaemic control, serving as a new alternative prescription for T2DM. Lusefi, with its active ingredient luseogliflozin hydrate, is available in the form of 2.5 mg and 5 mg tablets.
At a recent Abbott lunch symposium held in conjunction with the joint 12th International Diabetes FederationWestern Pacific Region Congress & 10th Asian Association for the Study of Diabetes Scientific Meeting in KualaLumpur, Professor Shashank R. Joshi extensively discussed the issue of diabetes in obesity and the role of nutritionalintervention in addressing this growing problem.
Dapagliflozin is able to delay renal disease progression among patients with type 2 diabetes, even in those with normal kidney function, according to a study presented at the recently concluded Kidney Week 2019 of the American Society of Nephrology (ASN 2019).
In pancreatic cancer patients undergoing chemotherapy, the presence of diabetes mellitus is associated with reduced survival and larger tumour, as well as with increased risk of death after treatment, according to a meta-analysis.