diabetes%20mellitus
DIABETES MELLITUS
Diabetes mellitus (DM) is a heterogenous metabolic disorder characterized by the presence of hyperglycemia with carbohydrate, protein and fat metabolism disturbance which results from defects in either insulin secretion or action.
Patients with DM usually present with polyuria, polydipsia and unexplained weight loss.
Type 1 DM is caused by beta cell destruction which leads to complete insulin deficiency. It may be immune mediated or idiopathic.
Patients may present with ketoacidosis or acute onset of hyperglycemia while other patients may resemble type 2 DM or symptoms of other autoimmune disorders.
Type 2 DM is the most common form of diabetes. It is secondary to defect in insulin secretion concomitant with insulin resistance.
Majority of patients are asymptomatic. Ketoacidosis is uncommon and is usually secondary to stress (eg infection).

Diabetes Mellitus Drug Information

Drug Information

Indication: NIDDM (type 2) in adults when dietary measures, physical exercise & wt loss alone are not sufficient to co...

Indication: Adjunct to diet & exercise to improve glycaemic control in adults ≥18 yr w/ type 2 DM as monotherapy; a...

Glyxambi
empagliflozin + linagliptin

Indication: Adjunct to diet & exercise to improve glycemic control in adults w/ type 2 DM when treatment w/ both empag...

Indication: Type 2 DM as monotherapy in adults inadequately controlled by diet & exercise alone & for whom metform...

Indication: Adjunct to diet & exercise to improve glycaemic control in adult patients w/ type 2 DM when treatment w/ b...

Lusefi
luseogliflozin hydrate

Indication: Monotherapy or add-on combination therapy w/ sulfonylurea in adult patients w/ type 2 DM.

Indication: Neuropathic pain in adults. Adjunctive therapy in adults w/ partial seizures w/ or w/o secondary generalisatio...

Qtern
dapagliflozin + saxagliptin

Indication: Adults ≥18 yr w/ type 2 DM inadequately controlled on metformin alone or when already treated w/ fixed-dose...

Indication: Adjunct to diet & exercise to improve glycemic control in adults w/ type 2 DM.

Indication: Adjunct to diet & exercise to improve glycaemic control in adults w/ type 2 DM.

1  /  18
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 2 days ago
Adding dapagliflozin to standard of care (SOC) significantly reduces the risk of worsening kidney function, death due to kidney or cardiovascular (CV) disease, and all-cause mortality compared with SOC alone in patients with chronic kidney disease (CKD), regardless of whether they have type 2 diabetes (T2D), reveals the DAPA-CKD* trial — showing dapagliflozin charting new territories from diabetes to the renal realm.
Roshini Claire Anthony, 2 days ago

In patients with chronic heart failure with reduced ejection fraction (HFrEF), empagliflozin reduced the risk of cardiovascular (CV) death or heart failure hospitalization (HHF) and decline in estimated glomerular filtration rate (eGFR), results of the EMPEROR-Reduced* trial showed.