diabetes%20mellitus%20(pediatric)
DIABETES MELLITUS (PEDIATRIC)
Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both.
It can occur at any age and the earlier the onset, the more serious is the long-term damage, dysfunction and failure of various organs due to the chronic hyperglycemia with diabetes mellitus patients having <10 year in life span compared to non-DM patients.
Type 1 DM patients have complete insulin deficiency due to beta-cell destruction. It may be immune-mediated or idiopathic. More commonly occurs in children 7-15 year of age, but may occur at any age.
Type 2 DM patients have insulin resistance and relative insulin deficiency.
Neonatal DM is hyperglycemia that occurs in the first 6 months of life.
  1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2008 Jan;31(Suppl 1):S55-S60. http://www.ncbi.nlm.nih.gov/pubmed/18165338. PMID: 18165338
  2. American Diabetes Association. Standards of medical care in diabetes. Diabetes Care. 2008 Jan;31(Suppl 1):S12-S54. http://www.ncbi.nlm.nih.gov/pubmed/?term=18165335. PMID: 18165335
  3. Anand SG, Mehta SD, Adams WG. Diabetes mellitus screening in pediatric primary care. Pediatrics. 2006 Nov;118(5):1888-1895. PMID: 17079559
  4. Craig ME, Hattersley A, Donaghue K, et al. ISPAD Clinical Practice Consensus Guidelines 2006-2007. Definition, epidemiology and classification. Pediatr Diabetes. 2006 Dec;7(6):343-351. http://www.ncbi.nlm.nih.gov/pubmed/?term=17212603. PMID: 17212603
  5. Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics. 2005 Aug;116(2):473-480. http://www.ncbi.nlm.nih.gov/pubmed/?term=16061606. PMID: 16061606
  6. Rodbard HW, Blonde L, Braithwaite SS, et al; AACE Diabetes Mellitus Clinical Practice Guidelines Task Force. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocr Pract. 2007;13(Suppl 1):001-68. PMID: 17613449
  7. Silverstein J, Klingensmith G, Copeland K, et al. Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. Diabetes Care. 2005 Jan;28(1):186-212. PMID: 15616254
  8. Type 2 diabetes in children and adolescents. American Diabetes Association. Diabetes Care. 2000 Mar;23(3):381-389. PMID: 10868870
  9. Alemzadeh R, Wyatt DT. Diabetes mellitus. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson textbook of Pediatrics. 18th ed. Philadelphia: Saunders, Elsevier; 2007
  10. MedWormhttp://www.medworm.com/rss/index.php/Endocrinology/15/http://www.medworm.com/rss/medicalfeeds/specialities/Endocrinology.xml
  11. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  12. Australasian Paediatric Endocrine Group for the Department of Health and Ageing. Clinical practice guidelines: Type 1 diabetes in children and adolescents. Canberra: Commonwealth of Australia. http://www.nhmrc.gov.au/publications. 2005
  13. National Diabetes Education Program. Overview of diabetes in children and adolescents. Bethesda: National Diabetes Education Program. http://www.ndep.nih.gov/diabetes/pubs/Youth_FactSheet.pdf. Aug 2006
  14. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014 Jan;37(Suppl 1):S81-S90. http://care.diabetesjournals.org. Accessed 18 Feb 2014. PMID: 24357215
  15. American Diabetes Association. Standards of medical care in diabetes - 2014. Diabetes Care. 2014 Jan;37(Suppl 1):S14-S80. http://care.diabetesjournals.org. PMID: 24357209
  16. Copeland KC, Silverstein J, Moore KR, et al; American Academy of Pediatrics. Management of newly diagnosed type 2 Diabetes Mellitus (T2DM) in children and adolescents. Pediatrics. 2013 Feb;131(2):364-382. http://pediatrics.aappublications.org/content/131/2/364.full.pdf. Accessed 20 Mar 2014. PMID: 23359574
  17. Flint A, Arslanian S. Treatment of type 2 diabetes in youth. Diabetes Care. 2011 May;34(2):S117-S183. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632158/pdf/S177.pdf. PMID: 21525452
  18. Springer SC, Silverstein J, Copeland K, et al; American Academy of Pediatrics. Management of type 2 diabetes mellitus in children and adolescents. Pediatrics. 2013 Feb;131(2):e648-e664. http://pediatrics.aappublications.org/content/131/2/e648.full.pdf+html. PMID: 23359584
  19. American Diabetes Association. Standards of medical care in diabetes – 2016. Diabetes Care. 2016 Jan;39(Suppl 1):S1-119. http://care.diabetesjournals.org. Accessed 05 Feb 2016
  20. Handelsman Y, Bloomgarden ZT, Grunberger G, et al. American Association of Clinical Endocrinologists and American College of Endocrinology - clinical practice guidelines for developing a diabetes mellitus comprehensive care plan - 2015. Endocr Pract. 2015 Apr;21(Suppl 1):1-87. doi: 10.4158/EP15672.GL. PMID: 25869408
  21. National Institute for Health and Care Excellence. Diabetes (type 1 and type 2) in children and young people: diagnosis and management. National Institute for Health and Care Excellence (NICE) Web Site. http://www.nice.org.uk/guidance/ng18/evidence/full-guideline-435396349. Aug 2015.
  22. Jackson CC, Albanese-O'Neill A, Butler KL, et al. Diabetes care in the school setting: a position statement of the American Diabetes Association. Diabetes Care. 2015 Oct;38(10):1958-1963. http://care.diabetesjournals.org/content/38/10/1958.full.pdf. PMID: 26404925
  23. Ministry of Health Malaysia. Clinical practice guidelines: management of type 2 diabetes mellitus. 5th ed. Ministry of Health Malaysia Web Site. http://www.moh.gov.my/attachments/CPG%20T2DM%202015%20Special%20AFES%20Congress%20Edition.pdf. Dec 2015.
  24. American Diabetes Association. Standards of medical care in diabetes - 2018. American Diabetes Association. http://care.diabetesjournals.org/. Jan 2018.
  25. Beck J, Greenwood D, Blanton L, et al. 2017 National standards for diabetes self-management education and support. Diabetes Care. 2017 Oct;40:1409-1419. doi: 10.2337/dci17-0025. Accessed 10 Jan 2019. PMID: 28754780
  26. Glaser N. Treatment and complications of diabetic ketoacidosis in children & adolescents. UpToDate. http://www.uptodate.com. Jul 2018. Accessed 10 Jan 2019.
  27. UpToDate. Insulin Aspart: Drug information. UpToDate. http://www.uptodate.com. 2019. Accessed 10 Jan 2019.
  28. UpToDate. Insulin lispro: Pediatric drug information. UpToDate. http://www.uptodate.com. 2019. Accessed 10 Jan 2019.
  29. Laffel L, Svoren B. Management of type 2 diabetes mellitus in children and adolescents. UpToDate. https://www.uptodate.com. Apr 2018.
  30. Wolfsdorf J, Glaser N, Agus M, et al. ISPAD Clinical practice consensus guidelines 2018: Diabetic ketoacidosis and the hyperglycemic hyperosmolar state. Pediatr Diabetes. 2018 Oct;19(Suppl 27):155-177. doi: 10.1111/pedi.12701. Accessed 10 Jan 2019. PMID: 29900641
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