Tumour size, grade, sex, race, and age at diagnosis are all associated with survival in patients with cutaneous pleomorphic sarcoma (CPS), suggests a study. Additionally, surgical tumour extirpation confers a survival benefit over no treatment, while primary or adjuvant radiation does not.
Cetirizine drip for treating acute urticaria is as effective as intravenous diphenhydramine, with the added benefits of less sedation, fewer adverse events, shorter treatment time, and lower rates of revisit to treatment centre, according to the results of a phase III study.
Treatment with clascoterone cream 1% results in a favourable safety profile, with a low frequency of treatment-emergent adverse events (TEAEs) over 9 months, in patients with acne vulgaris, results of a recent study have shown.
The type I interferon receptor antibody anifrolumab reduced disease activity and flares in patients with moderate-to-severe active systemic lupus erythematosus (SLE), results of the TULIP-1 and TULIP-2 trials have shown.
Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.
Use of biologic medications to treat erythrodermic psoriasis (EP) is well-tolerated by and induces positive responses in patients, with a weak recommendation and limited quality of evidence in favour of infliximab, ustekinumab, ixekizumab, and guselkumab, a recent study has shown.
Brodalumab, risankizumab, and ixekizumab rank as the top three best performing biologic drugs for psoriasis, yielding the highest rates of complete clearance of lesions and scoring a high probability of being the most effective in the induction treatment phase, according to the results of a network meta-analysis.
Use of low-dose oral minoxidil is safe and effective in the treatment of androgenic alopecia and alopecia areata, in addition to demonstrating a big advantage over the topical formulation in terms of convenience and patient compliance, as reported in a systematic review.
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.